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I0775020

Isosorbide 2-nitrate

European Pharmacopoeia (EP) Reference Standard

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Empirical Formula (Hill Notation):
C6H9NO6
CAS Number:
Molecular Weight:
191.14
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

isosorbide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5-,6-/m1/s1

InChI key

YWXYYJSYQOXTPL-JGWLITMVSA-N

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1 of 4

This Item
BP799Y0000106N0750015
vibrant-m

I0775020

Isosorbide 2-nitrate

vibrant-m

BP799

Isosorbide 2-nitrate

Nifedipine impurity B European Pharmacopoeia (EP) Reference Standard

N0750015

Nifedipine impurity B

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

isosorbide

API family

-

API family

pilocarpine

API family

nifedipine

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isosorbide 2-nitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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T B Tzeng et al.
Journal of chromatography, 571(1-2), 109-120 (1991-11-15)
A specific, sensitive and precise capillary gas chromatographic method using electron-capture detection was developed for the determination of four isomeric vasodilating organic mononitrates, viz. L-isoidide mononitrate (L-IIMN), isosorbide-2-mononitrate (IS-2-MN), isomannide mononitrate (IMMN) and isosorbide-5-mononitrate (IS-5-MN), in rat plasma. With a
M G Bogaert
Cardiovascular drugs and therapy, 8(5), 693-699 (1994-10-01)
The pharmacokinetics of organic nitrates are discussed with emphasis on the possible clinical relevance. For glyceryl trinitrate, the measurement of plasma concentrations is very difficult. Its pharmacokinetics are unusual, with a very rapid disappearance from plasma, and large intraindividual and
R De Caterina et al.
American heart journal, 119(4), 855-862 (1990-04-01)
Isosorbide monitrates (IS-2-MN and IS-5-MN), hepatic metabolites of isosorbide dinitrate, inhibit platelet function in vitro very differently, with IS-2-MN being much more potent than IS-5-MN. To assess their antiplatelet properties in vivo and to compare time and dosage requirements, we
Riccardo Raddino et al.
Journal of cardiovascular medicine (Hagerstown, Md.), 11(7), 486-492 (2010-04-24)
Nitrates are used in the treatment of coronary heart disease and heart failure. The major drawback of their therapeutic use is the rapid development of tolerance. To investigate the effect of different nitrates on isolated rabbit hearts and aortic strips
R Atanassova et al.
Archives internationales de pharmacodynamie et de therapie, 312, 104-109 (1991-07-01)
The effects of isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN) on vascular smooth muscle tone and on cyclic nucleotide levels were studied in isolated dog aorta. The effects of the mononitrates were compared with that of the relatively well-studied vasorelaxing agent sodium

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