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PHR1057

Supelco

Furosemide

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
FUR, 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Empirical Formula (Hill Notation):
C12H11ClN2O5S
CAS Number:
Molecular Weight:
330.74
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 547
traceable to Ph. Eur. F0700000
traceable to USP 1287008

API family

furosemide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

220 °C (dec.) (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

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This Item
1287008Y0001493F4381
Furosemide Pharmaceutical Secondary Standard; Certified Reference Material

PHR1057

Furosemide

Furosemide United States Pharmacopeia (USP) Reference Standard

1287008

Furosemide

Furosemide

F4381

Furosemide

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

format

neat

format

neat

format

neat

format

-

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

200

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

storage temp.

room temp

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is a diuretic drug, which finds a variety of therapeutic applications such as hepatic cirrhosis, cardiac insufficiency and arterial hypertension.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Furosemide is classified under the group of loop diuretics. It is used for the prevention of hypertension linked to renal and cardiac insufficiency.

Application

Furosemide may also be used as a reference standard in determining the concentration of furosemide present in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS). Furosemide may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using diffuse reflectance spectroscopy.
Furosemide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry, spectrophotometry and high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Inhibits ion co-transport in the kidney.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7130 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Exclamation markHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Flow-Based Fluorimetric Determination of Furosemide in Pharmaceutical Formulations and Biological Samples: Use of Micelar Media to Improve Sensitivity
Silva S, et al.
Analytical Letters, 41(1), 66-79 (2008)
A novel application of immobilization on membranes for the separation and spectrofluorimetric quantification of amiloride and furosemide in pharmaceutical samples
MCP, et al.
Analytica Chimica Acta, 661(1), 85-90 (2010)
Determination of furosemide in pharmaceutical formulations by diffuse reflectance spectroscopy
Gotardo AM, et al.
Talanta, 64(2), 361-365 (2004)
Sensitive micro analysis of frusemide (furosemide) in bulk drug and formulations by visible spectrophotometry and high performance liquid chromatography (HPLC)
Basavaiah K and Chandrashekar U
Indian Journal of Chemical Technology, 249(1), 117-126 (2005)
Simultaneous Determination of the Diuretics Triamterene and Furosemide in Pharmaceutical Formulations and Urine by HPLC-EC
Barroso MB, et al.
Journal of Liquid Chromatography and Related Technologies, 19(2), 231-246 (1996)

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