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PHR1258

Supelco

Chloroquine phosphate

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Chloroquine diphosphate salt, N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Empirical Formula (Hill Notation):
C18H26ClN3 · 2H3PO4
CAS Number:
Molecular Weight:
515.86
Beilstein/REAXYS Number:
4223142
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic

Quality Level

grade

certified reference material
pharmaceutical secondary standard

agency

BP
EP
USP
traceable to USP 1118000

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

chloroquine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

storage condition

protect from light

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white to yellow

pH

3.5-4.5 (10% in aqueous solution, pH <6.0)

mp

200 °C (dec.) (lit.)

solubility

water: 50 g/L
benzene: practically insoluble
chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

Inchi Key

QKICWELGRMTQCR-UHFFFAOYSA-N

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1 of 4

This Item
C6628PHR1713PHR1782
vibrant-m

PHR1258

Chloroquine phosphate

vibrant-m

C6628

Chloroquine diphosphate salt

vibrant-m

PHR1713

Proguanil hydrochloride

vibrant-m

PHR1782

Hydroxychloroquine Sulfate

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

300

format

neat

format

-

format

neat

format

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

packaging

pkg of 1 g

packaging

-

packaging

pkg of 1 g

packaging

pkg of 1 g

storage temp.

2-8°C

storage temp.

-

storage temp.

2-30°C

storage temp.

2-30°C

General description

Chloroquine phosphate is a phosphate salt of chloroquine. It belongs to the class of aminoquinoline drugs utilized as antimalarials and amebicides.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

application

Chloroquine phosphate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by thin-layer chromatography (TLC) and liquid chromatography (LC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3715 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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1118350

Chloroquine Related Compound D

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BP1100

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2-Chloroquinoxaline 98%

Sigma-Aldrich

136301

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Lys05 &#8805;98% (HPLC)

Sigma-Aldrich

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Lys05

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Sigma-Aldrich

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USP

USP

1118394

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Rapid spectrofluorimetric determination of chloroquine phosphate tablets
Nelson O, et al.
International Journal of Drug Development and Research, 2(2), 412-417 (2010)
Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine
Sahraei Z, et al.
International Journal of Antimicrobial Agents, 105945(10.1016) (2020)
Kazuhito Sasaki et al.
Anti-cancer drugs, 23(7), 675-682 (2012-05-09)
Autophagy is a complex of adaptive cellular response that enhances cancer cell survival in the face of cellular stresses such as chemotherapy. Recently, chloroquine diphosphate (CQ), a widely used antimalarial drug, has been studied as a potential inhibitor of autophagy.
David Tordrup et al.
Malaria journal, 10, 15-15 (2011-01-25)
Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes. This study presents a P. ovale isolate from a patient infected in Ghana together
Michel Michaelides et al.
Archives of ophthalmology (Chicago, Ill. : 1960), 129(1), 30-39 (2011-01-12)
To report the detailed clinical findings of patients with retinal toxicity that developed secondary to the use of hydroxychloroquine sulfate (n = 13), chloroquine phosphate (n = 2), or a combination of the agents (n = 1). Ophthalmologic examination, fundus

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