45999

Methyl acetate

suitable for HPLC, ≥99.8%

• Linear Formula: CH₃COOCH₃
• CAS Number: 79-20-9
• Molecular Weight: 74.08
• Beilstein/REAXYS Number: 1736662
• EC Number: 201-185-2
• MDL number: MFCD00008711
• UNSPSC Code: 12190000
• PubChem Substance ID: 329757046
• NACRES: NA.01

Properties

• vapor density: 2.55 (vs air)
• vapor pressure: 165 mmHg ( 20 °C)
• assay: ≥99.8% (GC); ≥99.8%
• form: liquid
• autoignition temp.: 936 °F
• shelf life: limited shelf life, expiry date on the label
• expl. lim.: 16 %
• technique(s): HPLC: suitable
• impurities: ≤0.05% water
• evapn. residue: ≤0.001%
• refractive index: n20/D 1.361 (lit.); n20/D 1.362
• bp: 57-58 °C (lit.)
• mp: −98 °C (lit.)
• density: 0.934 g/mL at 25 °C
• solvent strength ε (Al2O3): 0.60
• λ: 1 cm path, H₂O reference
• UV absorption: λ: 255 nm A_max: 1.0; λ: 275 nm A_max: 0.1; λ: 300 nm A_max: 0.01
• SMILES string: COC(C)=O
• InChI: 1S/C3H6O2/c1-3(4)5-2/h1-2H3
• InChI key: KXKVLQRXCPHEJC-UHFFFAOYSA-N

Description

Application

• Agglomeration of celecoxib by quasi-emulsion solvent diffusion method without stabilizer: effect of good solvent.: This research explored the agglomeration of celecoxib using the quasi-emulsion solvent diffusion method, highlighting the role of methyl acetate as a good solvent to improve particle size and distribution without the need for stabilizers (Maghsoodi & Nokhodchi, 2018).
• Formulation and in vitro evaluation of ketoprofen in palm oil esters nanoemulsion for topical delivery.: The formulation and evaluation of ketoprofen in a nanoemulsion system for topical delivery were examined, with methyl acetate used as a solvent to enhance solubility and stability of the active ingredient (Sakeena et al., 2010).
• Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating.: This paper presented a method for preparing surfactant-free nanoparticles using methyl acetate as a solvent, emphasizing its role in the formation of uniform nanoparticle dispersions for coating applications (Nguyen et al., 2006).

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Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319,H336
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Central nervous system
• supp_hazards: EUH066
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 8.6 °F - closed cup
• flash_point_c: -13 °C - closed cup