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235R-1

Sigma-Aldrich

CDX-2 (EPR2764Y) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EPR2764Y, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (235R-14)
vial of 0.5 mL concentrate (235R-15)
bottle of 1.0 mL predilute (235R-17)
vial of 1.0 mL concentrate (235R-16)
bottle of 7.0 mL predilute (235R-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

control

colon

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... CDX2(1045)

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This Item
102R-1384R-1102M-1
clone

EPR2764Y, monoclonal

clone

EP222, monoclonal

clone

EP281, monoclonal

clone

MRQ-11, monoclonal

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

Gene Information

human ... CDX2(1045)

Gene Information

human ... CD2(914)

Gene Information

human ... SATB2(23314)

Gene Information

human ... CD2(914)

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General description

CDX-2 is a caudal-related homeobox transcription factor that plays a role in the development and maintenance of intestinal mucosa. This protein is expressed in the normal and neoplastic gastrointestinal epithelium, including colorectal adenocarcinoma. It is useful for identifying the gastrointestinal origin of benign and malignant lesions.

Quality


IVD

IVD

IVD

RUO

Linkage

CDX-2 Positive Control Slides, Product No. 235S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Gabriel M Groisman et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 23(1), 52-57 (2003-12-12)
Histologic differentiation of primary ovarian carcinoma from colonic carcinoma metastatic to the ovary may be difficult. Cytokeratin 7 (CK7) and cytokeratin 20 (CK20) immunostaining is usually used, but these markers lack specificity for ovarian and intestinal epithelium, and overlapping results
Anjali Saqi et al.
American journal of clinical pathology, 123(3), 394-404 (2005-02-18)
Carcinoids of different organs appear morphologically indistinguishable. We studied the usefulness of differential expression of CDX2 and thyroid transcription factor-1 (TTF-1) in 78 gastrointestinal and pulmonary carcinoids and their metastases (n = 10). CDX2 staining of gastric biopsy specimens with
Lori A Erickson et al.
Endocrine pathology, 15(3), 247-252 (2005-01-11)
The transcription factors CDX1 and CDX2 are homeobox genes that regulate development of the epithelium of the small and large intestine. A few studies have shown that Cdx2 protein expression is useful in the diagnosis of adenocarcinomas as well as
Robert M Mazziotta et al.
Applied immunohistochemistry & molecular morphology : AIMM, 13(1), 55-60 (2005-02-22)
Paraffin-embedded sections of various adenocarcinomas (13 colonic, 11 mucinous ovarian, 5 serous ovarian, 8 pancreatic, 6 ampullary, 12 gastric, 5 esophageal, 10 endometrial, 29 breast, and 55 lung) and 29 additional lung carcinomas (nonadenocarcinomas) were immunostained with antibodies to CDX2
Robert W Werling et al.
The American journal of surgical pathology, 27(3), 303-310 (2003-02-27)
CDX2 is a recently cloned homeobox gene that encodes an intestine-specific transcription factor, expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. While expression of CDX2 protein in primary and metastatic colorectal carcinomas has been

Articles

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

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