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Sigma-Aldrich

MAPTrix Reagent

Low Molecular Weight, lyophilized powder

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NACRES:
NA.75

sterility

sterile

form

lyophilized powder

mol wt

~22.6 kDa

packaging

pkg of 100 mg
pkg of 5 mg

technique(s)

cell culture | mammalian: suitable

shipped in

ambient

storage temp.

2-8°C

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Sigma-Aldrich

26001K

MAPTrix Reagent

Sigma-Aldrich

160012K

MAPTrix Reagent

Sigma-Aldrich

160014K

MAPTrix Reagent

Sigma-Aldrich

160022K

MAPTrix Reagent

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

form

lyophilized powder

form

aqueous solution

form

aqueous solution

form

aqueous solution

mol wt

~22.6 kDa

mol wt

~22.6 kDa

mol wt

~22.6 kDa

mol wt

~36.8 kDa

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

packaging

pkg of 100 mg, pkg of 5 mg

packaging

pkg of 2.5 mg

packaging

pkg of 10 mg

packaging

pkg of 2.5 mg

General description

MAPTrix Reagent intended for use as adhesive hydrogel or dispersion agent.

Application

MAPTrix Technology provides a true extracellular microenvironment (ECM) by presenting combinatorial peptide motifs. The ECM, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.Currently existing technology offers simple and merely adequate environments that facilitate simple cell processes such as cellular adhesion. The simple presentation of cell adhesion motifs is not optimal for controlling more integrated processes. Crosstalk among signaling pathways act synergistically to enhance cellular responses such as cell adhesion or proliferation. A study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly. The combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.

Features and Benefits

  • Biochemically-defined, animal-free cell culture surfaces designed to enhance cell performance
  • MAPTrix produces a uniform ECM surface that provides a highly controlled 2D extracellular microenvironment for cell cultures and related applications
  • Adhesion properties of the mussel adhesive protein makes the coating reproducible & reliable

Legal Information

MAPTrix is a trademark of Kollodis Biosciences

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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Seung Tae Lee et al.
Biomaterials, 31(6), 1219-1226 (2009-11-21)
We present development and use of a 3D synthetic extracellular matrix (ECM) analog with integrin-specific adhesion ligands to characterize the microenvironmental influences in embryonic stem cell (ESC) self-renewal. Transcriptional analysis of 24 integrin subunits followed by confirmation at the translational
Samuel Schmidt et al.
Cell and tissue research, 339(1), 83-92 (2009-11-19)
Adhesion and migration are integrated cell functions that build, maintain and remodel the multicellular organism. In migrating cells, integrins are the main transmembrane receptors that provide dynamic interactions between extracellular ligands and actin cytoskeleton and signalling machineries. In parallel to
Ying Meng et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(4), 1056-1065 (2009-11-26)
Human embryonic stem (hES) cells are pluripotent, capable of differentiating into any cell type of the body, and therefore have the ability to provide insights into mechanisms of human development and disease, as well as to provide a potentially unlimited
Stephanie J Ellis et al.
Cell and tissue research, 339(1), 121-130 (2009-07-10)
The regulation of stem cell behavior and maintenance typically involves the integration of both intrinsic and extrinsic cues. One such external cue, integrin-mediated cell adhesion to the extracellular matrix, plays an important part in regulating stem cell function and maintenance.
S J Fashena et al.
Nature cell biology, 2(12), E225-E229 (2001-01-09)
Over the past twenty years, intensive research has enabled us to identify components of specific signalling pathways downstream of an array of adhesion and growth-factor receptors. The first Gordon Research Conference on 'Signalling by Adhesion Receptors', which took place in

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