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27840

Sigma-Aldrich

Corticosterone

≥98.5% (HPLC)

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Synonym(s):
11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H
Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
Molecular Weight:
346.46
Beilstein/REAXYS Number:
2339601
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

assay

≥98.5% (HPLC)

form

powder or crystals

optical activity

[α]20/D +223±3°, c = 1% in ethanol

mp

179-183 °C (lit.)
179-183 °C

functional group

ketone

SMILES string

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Gene Information

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This Item
C2505H4001P9521
Corticosterone ≥98.5% (HPLC)

27840

Corticosterone

Corticosterone ≥92%

C2505

Corticosterone

Hydrocortisone ≥98% (HPLC)

H4001

Hydrocortisone

21-Deoxycortisol

P9521

21-Deoxycortisol

functional group

ketone

functional group

-

functional group

-

functional group

-

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

synthetic (organic)

form

powder or crystals

form

powder

form

powder

form

powder

mp

179-183 °C (lit.)

mp

179-183 °C (lit.)

mp

211-214 °C (lit.)

mp

-

optical activity

[α]20/D +223±3°, c = 1% in ethanol

optical activity

-

optical activity

-

optical activity

-

General description

Corticosterone (Cort) is a glucocorticoid hormone. It is also the principal hormone that mediates stress responses in birds. It is the primary adrenal cortical steroid in rat plasma. The influence of maternal Cort exposure on the developing placenta has been studied in a mouse model.

Application

Corticosterone was used to study the adrenoceptor signaling in rats, lizards or in vitro. It was also used in immune suppression experiment.

Biochem/physiol Actions

Corticosterone is synthesized from cholesterol in the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors. The role of corticosterones is vital for reproductive processes including ovulation, lutenization, development of oocytes, parturition and lactation. The metabolism of corticosterone is modulated by the enzyme 11β-hydroxysteroid dehydrogenase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Corticosterone is soluble in chloroform and ethanol.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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CORTICOSTERONE 21-ACETATE AldrichCPR

R199877

CORTICOSTERONE 21-ACETATE

21-Deoxycortisol

Sigma-Aldrich

P9521

21-Deoxycortisol

Hydrocortisone ≥98% (HPLC)

Sigma-Aldrich

H4001

Hydrocortisone

Stress, corticosterone responses and avian personalities.
Cockrem JF.
Journal of Ornithology, 148(2), 169-178 (2007)
Corticosterone and brood abandonment in a passerine bird.
Ouyang JQ, et al.
Animal behaviour, 84(1), 261-268 (2012)
Bryan E LaFonte et al.
The Journal of experimental biology, 216(Pt 19), 3700-3708 (2013-07-04)
Although naturally occurring hosts often exhibit pronounced differences in infection and pathology, the relative importance of factors associated with host life history and immunity in explaining such patterns often remains speculative. Research in eco-immunology highlights the trade-offs between host physiology
Anthony E Michael et al.
Reproduction (Cambridge, England), 126(4), 425-441 (2003-10-04)
Within potential target cells, the actions of physiological glucocorticoids (cortisol and corticosterone) are modulated by isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD). To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts
J C Doxey et al.
British journal of pharmacology, 60(1), 91-96 (1977-05-01)
1. Low frequency (0.1 Hz) electrical stimulation of the rat isolated vas deferens produced regular contractions that were inhibited by low concentrations of clonidine. 2. The inhibition of the vas deferens produced by clonidine was presynaptic in origin and involved

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