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384R-1

Sigma-Aldrich

SATB2 (EP281) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP281, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (384R-14)
vial of 0.5 mL concentrate (384R-15)
bottle of 1.0 mL predilute (384R-17)
vial of 1.0 mL concentrate (384R-16)
bottle of 7.0 mL predilute (384R-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG

control

colon adenocarcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... SATB2(23314)

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This Item
235R-1431R-1343R-1
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

clone

EP281, monoclonal

clone

EPR2764Y, monoclonal

clone

EP283, monoclonal

clone

EP229, monoclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

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General description

Special AT-rich sequence-binding protein 2 (SATB2) is a marker that functions as a nuclear matrix-associated transcription factor that has been shown to identify colorectal carcinomas, including poorly differentiated colorectal carcinomas and metastases. Adenocarcinomasincluding breast, lung, and ovary may express SATB2 at lower frequencies.1 Therefore, SATB2 is useful for identifying a carcinoma of colorectal origin when identifying a cancer of unknown primary.

Quality


IVD

IVD

IVD

RUO

Linkage

SATB2 Positive Control Slides, Product No. 384S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Michelle Moh et al.
The American journal of surgical pathology, 40(3), 419-432 (2015-11-10)
The primary origin of some ovarian mucinous tumors may be challenging to determine, because some metastases of extraovarian origin may exhibit gross, microscopic, and immunohistochemical features that are shared by some primary ovarian mucinous tumors. Metastases of primary colorectal, appendiceal
Anca Dragomir et al.
American journal of clinical pathology, 141(5), 630-638 (2014-04-10)
Immunohistochemistry is an important extension to clinical information and morphology, and prevails as an invaluable tool for establishing a correct cancer diagnosis in clinical diagnostic pathology. The applicability of immunohistochemistry is limited by the availability of validated cell- and cancer-type
Yi-Jun Zhang et al.
EBioMedicine, 28, 62-69 (2018-02-06)
SATB2 (Special AT-rich sequence-binding protein 2) has recently been shown to be a specific biomarker of colorectal cancer (CRC). The aim of this study was to investigate the diagnostic potential of SATB2 as a means of detecting a CRC origin
Fan Lin et al.
Archives of pathology & laboratory medicine, 138(8), 1015-1026 (2014-01-21)
Distinction of medullary carcinoma of the large intestine from other cytokeratin (CK) 7⁻/CK20⁻ carcinomas can be challenging when working on a tumor of unknown primary because the majority of medullary carcinomas are negative for CK7, CK20, and CDX2. To investigate
Stefan M Brettfeld et al.
Archives of pathology & laboratory medicine, 143(9), 1119-1125 (2019-03-07)
Metastatic mucinous tumors present a diagnostic challenge for pathologists as tumor histomorphology is often nonspecific and optimal immunoprofiles are still under investigation. To present a head-to-head comparison of special AT-rich sequence-binding protein 2 (SATB2) and caudal type homeobox 2 (CDX2)

Articles

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

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A brief overview on diagnostic immunohistochemistry (IHC) and its importance in modern clinical pathology. Learn more about IHC and its role in cancer diagnosis and the detection of infectious diseases.

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