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395R-1

Sigma-Aldrich

c-Myc (EP121) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP121, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (395R-14)
vial of 0.5 mL concentrate (395R-15)
bottle of 1.0 mL predilute (395R-17)
vial of 1.0 mL concentrate (395R-16)
bottle of 7.0 mL predilute (395R-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG

control

Burkitt lymphoma, prostate carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... MYC(4609)

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MABE282C3956ABE26
Anti-c-Myc Antibody, clone 9E10 clone 9E10, from mouse

MABE282

Anti-c-Myc Antibody, clone 9E10

Anti-acetyl-c-Myc (Lys323) Antibody from rabbit, purified by affinity chromatography

ABE26

Anti-acetyl-c-Myc (Lys323) Antibody

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

mouse, human

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

antibody form

culture supernatant

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

-

Gene Information

human ... MYC(4609)

Gene Information

human ... MYC(4609)

Gene Information

human ... MYC(4609)

Gene Information

chimpanzee ... Myc(464393)
human ... MYC(4609)
mouse ... Myc(17869)
rhesus monkey ... Myc(694626)

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General description

c-Myc is a transcription factor that drives the growth and proliferation of cells. c-Myc isamplified in many different solid and hematopoietic tumors. Immunohistochemistry forc-Myc protein is used to identify the presence of a c-Myc translocation in various tumors,most frequently to aid in the diagnosis of Burkitt lymphoma.

Quality


IVD

IVD

IVD

RUO

Linkage

c-Myc Positive Control Slides, Product No. 395S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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1000309185

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Christopher W Toon et al.
PloS one, 9(2), e87456-e87456 (2014-02-08)
MYC over-expression as determined by molecular means has been reported as a favorable prognostic biomarker in colorectal carcinoma (CRC). However MYC expression analysis is not available in the routine clinical setting. We investigated whether immunohistochemistry (IHC) for the myc protein
c-Myc target genes involved in cell growth, apoptosis, and metabolism.
C V Dang
Molecular and cellular biology, 19(1), 1-11 (1998-12-22)
Rakesh Naidu et al.
International journal of molecular medicine, 9(2), 189-196 (2002-01-12)
Overexpression of c-myc protein and amplification of c-myc were investigated by immunohistochemistry and differential polymerase chain reaction (dPCR) in 440 formalin-fixed primary breast carcinoma tissues, respectively. Overexpression of c-myc was detected in 45% (199/440) and amplification of c-myc was observed
Tina Marie Green et al.
The American journal of surgical pathology, 36(4), 612-619 (2012-02-09)
Determining the presence of MYC gene rearrangements is becoming an increasingly important part of the diagnostic workup in aggressive lymphoma. Cytogenetic MYC alterations aid in differentiating diffuse large B-cell lymphoma (DLBCL) from Burkitt lymphoma. In addition, MYC aberrations are associated
Bora Gurel et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(9), 1156-1167 (2008-06-24)
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function and stem cell renewal. A region on chromosome 8q24 encompassing the MYC locus is amplified in prostate cancer, but this occurs mostly in advanced

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