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Sigma-Aldrich

L-α-Lysophosphatidylinositol sodium salt from soybean

≥98.0% (TLC)

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Synonym(s):
1-Acyl-sn-glycero-3-phospho-(1-D-myo-inositol)
MDL number:
NACRES:
NA.25

biological source

soybean

Quality Level

assay

≥98.0% (TLC)

form

powder

impurities

primarily palmitic acid
stearic acid

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

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This Item
L7635P0639P6636
assay

≥98.0% (TLC)

assay

≥96%

assay

≥99%

assay

-

functional group

phospholipid

functional group

phospholipid

functional group

phospholipid

functional group

phospholipid

form

powder

form

powder

form

powder

form

crude powder

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Biochem/physiol Actions

Lysophosphatidylinositol, an endogenous phospholipid, is a novel ligand for the orphan G protein-coupled receptor 55 (GPR55) . Lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT (nuclear factor of activated T cells) activation in human embryonic kidney 293 cells .

Preparation Note

by phospholipase A2-treatment of 3-sn-phosphatidylinositol

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Saori Oka et al.
Biochemical and biophysical research communications, 362(4), 928-934 (2007-09-04)
GPR55 is an orphan G protein-coupled receptor. In this study, we explored a possible endogenous ligand for GPR55 using HEK293 cells which expressed GPR55. We found that lysophosphatidylinositol induced rapid phosphorylation of the extracellular signal-regulated kinase in transiently or stably
Christopher M Henstridge et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(1), 183-193 (2008-09-02)
The endogenous phospholipid l-alpha-lysophosphatidylinositol (LPI) was recently identified as a novel ligand for the orphan G protein-coupled receptor 55 (GPR55). In this study we define the downstream signaling pathways activated by LPI in a human embryonic kidney (HEK) 293 cell

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