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A5566

Sigma-Aldrich

Monoclonal Anti-α1-Acid Glycoprotein antibody produced in mouse

clone AGP-47, ascites fluid

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MDL number:
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

AGP-47, monoclonal

contains

15 mM sodium azide

species reactivity

human, baboon (weakly)

should not react with

canine, bovine

technique(s)

dot blot: suitable
indirect ELISA: suitable
western blot: 1:10,000

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ORM1(5004)

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T6557A2672G8021
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... ORM1(5004)

Gene Information

human ... TUBG1(7283)
mouse ... Tubg1(103733)
rat ... Tubg1(252921)

Gene Information

human ... ALB(213)

Gene Information

Escherichia coli ... lacZ(1036228), lacZ(1036228)
Escherichia coli K12 ... Lacz(945006)

clone

AGP-47, monoclonal

clone

GTU-88, monoclonal

clone

HSA-9, monoclonal

clone

GAL-13, monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

species reactivity

human, baboon (weakly)

species reactivity

rat, hamster, chicken, human, bovine, canine, Xenopus, mouse

species reactivity

rhesus monkey, baboon, human

species reactivity

bacteria

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General description

Monoclonal Anti-α1-Acid Glycoprotein (mouse IgG1 isotype) is derived from the AGP-47 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. α1-Acid Glycoprotein (AGP) is an acute-phase plasma protein. This protein is mainly produced in the hepatocytes. AGP1 gene is mapped on the human chromosome at 9q32.

Specificity

Recognizes an epitope located on the 44 kDa subunit of denatured-reduced AGP using the immunoblotting technique. It does not cross react with human serum amyloid P component, human haptoglobin, human C-reactive protein, and human IgG.

Immunogen

human α1-acid glycoprotein (AGP).

Biochem/physiol Actions

α1-Acid Glycoprotein (AGP) associates with haptoglobin and C-reactive protein, which indicates inflammation. Higher levels of AGP is associated with various inflammatory diseases, trauma, malignancies, myocardial infarction, rheumatoid arthritis, after major surgery, and in cases of chronic pain. This protein is capable of binding and transporting basic and neutral drugs.

Physical form

The product is provided as ascites fluid with 0.1% sodium azide as a preservative.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Related product

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Mosale Seetharam Sumanth et al.
Journal of leukocyte biology, 109(5), 915-930 (2020-10-19)
Alpha-1-acid glycoprotein (AGP-1) is a positive acute phase glycoprotein with uncertain functions. Serum AGP-1 (sAGP-1) is primarily derived from hepatocytes and circulates as 12-20 different glycoforms. We isolated a glycoform secreted from platelet-activating factor (PAF)-stimulated human neutrophils (nAGP-1). Its peptide
Tino Hochepied et al.
Cytokine & growth factor reviews, 14(1), 25-34 (2002-12-18)
alpha(1)-Acid glycoprotein (AGP) is a protein with a molecular weight of 41-43 kDa and is heavily glycosylated (45%). Due to the presence of sialic acids, it is negatively charged (pI=2.7-3.2). AGP is an acute phase protein in all mammals investigated
Hiroko Shimazaki et al.
Current protocols in protein science, 99(1), e103-e103 (2020-02-20)
Lectin is a biomolecule that recognizes a specific part of glycans and, thus, has been used widely as a probe for glycoprotein analysis. Owing to the wide repertoire in nature combined with the recent two decades of advances in microarray
Lipocalin 2 in the pathogenesis of fatty liver disease and nonalcoholic steatohepatitis
Asimakopoulou A and Weiskirchen R
Clinical Lipidology, 10(1), 47-67 (2015)
Isabel Jaco et al.
Molecular cell, 66(5), 698-710 (2017-05-17)
TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase MK2, thereby promoting transcription, mRNA stabilization, and

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