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AC-0361

Sigma-Aldrich

Galectin-3 (EP412) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

Ig fraction of antiserum

clone

monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

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This Item
AC-0361A345830-M434R-1
biological source

rabbit

biological source

rabbit

biological source

-

biological source

rabbit

clone

monoclonal

clone

monoclonal

clone

-

clone

EP111, monoclonal

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

technique(s)

-

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200

isotype

IgG

isotype

IgG

isotype

-

isotype

IgG

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

General description

Galectin-3 (GAL3), encoded by LGALS3, is a member of the galectin family of β-galactoside-binding lectins. GAL3 is involved in many biological process, such as cell growth and differentiation, cell-cell and cell-matrix adhesion interactions, angiogenesis, and apoptosis. It is expressed in normal breast epithelial cells, inflammatory and various malignant cells. Recent investigators have found GAL3 involved in tumor progression and metastasis, and its expression valuable in differentiating between benign and malignant thyroid neoplasms. Thyroid carcinomas are histologically classified into four subtypes: papillary, follicular, medullary, and anaplastic/undifferentiated. The papillary and follicular carcinomas are derived from follicular epithelium while the medullary subtype is derived from parafollicular cells (C cells). Anaplastic carcinoma also originates from follicular epithelium, but are highly aggressive. GAL3 was expressed in most thyroid malignancies of epithelial origin from fine-needle aspirate and open biopsies. GAL3 did not stain normal thyroid tissues or benign follicular adenomas. In a panel of 5 diagnostic markers (GAL3, FN1, CITED1, CK19, and HBME1), GAL3 demonstrated the highest sensitivity and accuracy in the differential diagnosis of benign and malignant tumors with follicular architecture. Fibronectin 1 (FN1) and GAL3 co-expression was diagnostic of carcinoma; their absence was indicative for benign lesions. GAL3 may be a useful marker for thyroid carcinomas of follicular cell origin (including papillary, follicular, and anaplastic carcinomas).

Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and &< 0.1% Sodium Azide

Other Notes

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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