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AV32753

Sigma-Aldrich

Anti-OLIG2 (AB1) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-Oligodendrocyte lineage transcription factor 2
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

32 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... OLIG2(10215)

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Anti-Olig-2 Antibody Chemicon®, from rabbit

AB9610

Anti-Olig-2 Antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

conjugate

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Gene Information

human ... OLIG2(10215)

Gene Information

human ... OLIG2(10215)

Gene Information

human ... OLIG2(10215)

Gene Information

human ... OLIG2(10215)

UniProt accession no.

Q13516

UniProt accession no.

Q13516

UniProt accession no.

Q9EQW6

UniProt accession no.

Q13516

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General description

Oligodendrocyte lineage transcription factor 2 (OLIG2), a basic helix-loop-helix transcription factor, is an essential regulator of ventral neuroectodermal progenitor cell fate and is required for oligodendrocyte and motor neuron development. OLIG2 is a universal marker of diffuse gliomas including oligodendroglioma, astrocytoma, glioblastoma, and mixed glioma.
Rabbit polyclonal anti-OLIG2 antibody reacts with chicken, human, and mouse oligodendrocyte lineage transcription factor 2 transcription factors.

Immunogen

Synthetic peptide directed towards the C-terminal region of Human OLIG2

Application

Rabbit Anti-OLIG2 (AB1) antibody can be used for western blot applications at a concentration of 0.5 μg/ml.
Rabbit polyclonal anti-OLIG2 antibody is used to tag oligodendrocyte lineage transcription factor 2 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of oligodendrocyte lineage transcription factor 2 in ventral neuroectodermal progenitor cell fate and as a diffuse glioma marker protein.

Biochem/physiol Actions

OLIG2 is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. OLIG2 is an essential regulator of ventral neuroectodermal progenitor cell fate. It is associated with T-cell acute lymphoblastic leukemia due to a chromosomal translocation t(14;21)(q11.2;q22). OLIG2 might play a role in learning deficits associated with Down syndrome.

Sequence

Synthetic peptide located within the following region: AAVSSASLPGSGLPSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGASGGF

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Qiao Zhou et al.
Cell, 109(1), 61-73 (2002-04-17)
OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the pMN domain of the spinal cord, which sequentially generates motoneurons and oligodendrocytes. In Olig1/2 double-mutant mice, motoneurons are largely eliminated, and oligodendrocyte differentiation is abolished. Lineage tracing data suggest
Y Marie et al.
Lancet (London, England), 358(9278), 298-300 (2001-08-11)
OLIG2 is a recently identified transcription factor involved in the specification of cells in the oligodendroglial lineage. We investigated the expression of OLIG2 by in-situ hybridisation in 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas
Irene Bertolini et al.
EBioMedicine, 41, 225-235 (2019-02-10)
The V-ATPase proton pump controls acidification of intra and extra-cellular milieu in both physiological and pathological conditions. We previously showed that some V-ATPase subunits are enriched in glioma stem cells and in patients with poor survival. In this study, we

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