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B9688

Sigma-Aldrich

Pizotifen

≥98% (HPLC)

Synonym(s):

Pizotifen, Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine

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About This Item

Empirical Formula (Hill Notation):
C19H21NS
CAS Number:
15574-96-6
Molecular Weight:
295.44
EC Number:
239-632-9
MDL number:
MFCD00864192
UNSPSC Code:
12352200
PubChem Substance ID:
329773323
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

solubility

DMSO: ≥8 mg/mL

originator

Novartis

Storage temp.

room temp

SMILES string

CN1CCC(\CC1)=C2\c3ccccc3CCc4sccc24

InChI

1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3

InChI key

FIADGNVRKBPQEU-UHFFFAOYSA-N

Biochem/physiol Actions

Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H361

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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C E Serna-Jiménez et al.
Biomedical chromatography : BMC, 26(6), 769-774 (2011-10-18)
Pizotifen malate is an antihistamine and serotonin inhibitor used in the preventive treatment of migraine and eating disorders. A simple, rapid, accurate and precise high-performance liquid chromatography (HPLC) method involving ultraviolet detection was validated for the quantitative analysis of pizotifen
Abdeslam Chagraoui et al.
Psychopharmacology, 170(1), 17-22 (2003-08-09)
Agomelatine, an antidepressant with melatonin agonist and 5-HT(2C) antagonist properties, as well as two of its main metabolites, S 21517 (N-[2-(7-hydroxy-1-naphtyl)ethyl]acetamide) and S21540 (N-[2-(3-hydroxy-7-methoxynaphtalen-1-yl)ethyl]acetamide), have been assessed in vitro on pig choroid plexus preparations to determine their affinities for 5-HT(2C)
Richard Young et al.
Pharmacology, biochemistry, and behavior, 82(2), 404-410 (2005-10-29)
MDMA (N-methyl-3,4-methylenedioxyamphetamine) produces a discriminative stimulus (DS) effect in animals, but attempts to completely block this action with selective neurotransmitter antagonists have not been very successful. Biochemically, MDMA can increase synaptic levels of serotonin, dopamine, and norepinephrine that, conceivably, might
Paul Silcocks et al.
Trials, 11, 71-71 (2010-06-18)
A recent Cochrane Review demonstrated the remarkable lack of reliable clinical trials of migraine treatments for children, especially for the two most prescribed preventative treatments in the UK, Propranolol and Pizotifen.Migraine trials in both children and adults have high placebo
Charles Kwaku Benneh et al.
Journal of ethnopharmacology, 207, 129-145 (2017-06-25)
Maerua angolensis DC (Capparaceae) has been employed in the management of several central nervous system (CNS) disorders including anxiety. This study evaluated the anxiolytic effects of the petroleum ether/ethyl acetate fraction stem bark extract and its possible mechanism(s) using zebrafish
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