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C1740

Sigma-Aldrich

Complement component C1q from human serum

≥95% (SDS-PAGE)

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Synonym(s):
C1q from human serum
CAS Number:
MDL number:
NACRES:
NA.61

biological source

human

Quality Level

assay

≥95% (SDS-PAGE)

form

liquid

technique(s)

activity assay: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

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This Item
204876C3160C2910
vibrant-m

204876

Complement C1q, Human

vibrant-m

C3160

Complement C5 from human serum

vibrant-m

C2910

Complement C3 from human serum

biological source

human

biological source

-

biological source

human serum

biological source

human

assay

≥95% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥85% (SDS-GE)

Gene Information

human ... C1QA(712), C1QB(713), C1QC(714)

Gene Information

-

Gene Information

human ... C5(727)

Gene Information

human ... C3(718)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

liquid

form

liquid

form

solution

form

solution

General description

C1q, together with C1r and C1s, in the ratio of 1:2:2, form the C1 complex which is the first component of the classical complement pathway. C1q is composed of 18 polypeptide chains (six A, six B, six C) (MW 460 kDa). All contain an 81-aa collagen-like region composed of (Gly-Xaa-Yaa) repeating sequences close to the N-terminus. Three chains (A1B1C1) form a triple helix with the C-terminus forming the globular heads which may be structurally and functionally distinct domains.

application

Complement component C1q is an important regulator factor for platelet activation. This has been a topic for research, as platelet-leukocyte aggregates play an important role in inflammatory conditions such as coronary heart disease. In particular, C1q has been shown to inhibit collagen induced aggregation and enhance production of reactive oxygen species (ROS).

Biochem/physiol Actions

C1q deficiency, either because of rare homozygous genetic defect, or transcriptional/translational defects, is almost certainly a cause of systemic lupus erythematosus (SLE). The three C1q subunits are expressed through a novel mechanism of transcriptional synchronization.

Physical form

Supplied as a solution in 10 mM HEPES, 300 mM NaCl, pH 7.2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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