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Monoclonal Anti-Cathepsin L antibody produced in mouse

clone 33/2, ascites fluid

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Anti-CATL, Anti-CTSL, Anti-MEP
MDL number:

biological source


Quality Level



antibody form

ascites fluid

antibody product type

primary antibodies


33/2, monoclonal

mol wt

antigen (human cathepsin L) 25 kDa
antigen (human procathepsin L) 42 kDa


15 mM sodium azide

species reactivity

mouse, mink, human, rat


immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:200 using whole cell extract of a cultured mink lung cell line



UniProt accession no.

shipped in

dry ice

storage temp.


target post-translational modification


Gene Information

human ... CTSL1(1514)
mouse ... Ctsl(13039)
rat ... Ctsl1(25697)

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General description

Cathepsin L is a cysteine protease and is secreted by numerous transformed cells in its inactive pre-form. It is ubiquitously expressed and is localized in nucleus. Cathepsin L have substrate interacting region located in L and R domain loops.


Reacts specifically with native and denatured forms of human cathepsin L and procathepsin L. Recognizes an epitope within amino acid residues GYGFEST (265-271 in procathepsin L and 169-175 in the mature cathepsin L molecule). The antibody may be used for the suppression of the malignant growth of myeloma cells. Cross-reactivity is observed with rat cathepsin L (strong), mouse procathepsin L (weak) and mink cathepsin and procathepsin L. Does not cross-react with human cathepsin types B, D, H and S, procathepsins B and D, rat cathepsin B, and mouse procathepsins B and D.


procathepsin L isolated from the human lung cancer cell line EPLC 32M1.

Biochem/physiol Actions

Cathepsin L expression is correlated with the metastatic potential of transformed cells. Cathepsin L is capable of degrading protein constituents of the extracellular matrix, this enzyme is thought to play a crucial role in tumor progression, metastasis and other disorders where the destruction of the matrix is the major cause of disease.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids




Not applicable


Not applicable

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Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number
Lombardi G, et al.
Journal of Immunology, 174(11), 7022-7032 (2005)
Cysteine cathepsins: from structure, function and regulation to new frontiers
Turk V, et al
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1824(1), 68-88 (2012)
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation
Goulet B, et al.
Molecular Cancer Research, 5(9), 899-907 (2007)
Cathepsin L1, the Major Protease Involved in Liver Fluke (Fasciola hepatica) virulence propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells
Collins PR, et al.
Test, 279(17), 17038-17046 (2004)
Kazuyoshi Yanagihara et al.
Cancer science, 96(6), 323-332 (2005-06-17)
The number of published studies on peritoneal dissemination of scirrhous gastric carcinoma is very small as a result of the unavailability of highly reproducible animal models. Orthotopic implantation of HSC-44PE and HSC-58 (scirrhous gastric carcinoma-derived cell lines) cells into nude

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