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C5135

Sigma-Aldrich

Castor Oil, Ethoxylated

pH range 6.0-8.0

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Synonym(s):
Cremophor® EL, Kolliphor® EL, Macrogolglycerol ricinoleate, PEG-35 castor oil, Polyoxyl-35 castor oil
CAS Number:
MDL number:
NACRES:
NA.25

description

non-ionic

form

liquid

mol wt

~2500 g/mol

pH range

6.0-8.0

HLB

12 - 14

application(s)

sample preservation

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

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1 of 4

This Item
K4894W29150142966
vibrant-m

C5135

Castor Oil, Ethoxylated

vibrant-m

K4894

Poloxamer 188

vibrant-m

W291501

Polysorbate 20

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

100

description

non-ionic

description

-

description

Biological source: corn or palm

description

non-ionic

application(s)

sample preservation

application(s)

sample preservation

application(s)

flavors and fragrances

application(s)

sample preservation

HLB

12 - 14

HLB

-

HLB

-

HLB

-

mol wt

~2500 g/mol

mol wt

8.400 g/mol

mol wt

-

mol wt

-

General description

Kolliphor® EL is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide. It is a pale yellow oily liquid that is clear at temperatures above 26°C. It has a faint but characteristic odour.
Kolliphor® EL is polyethylene oxide surfactant and is viscous in nature. It has a hydrophobic-lipophilic balance value in the range of 12-14.

Application

Kolliphor® EL has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation. It has been used as a vehicle for drug/stimulant delivery in cells.

Biochem/physiol Actions

Kolliphor® EL is used in lipid-based formulations for drugs and solubilization of cosmetics. Kolliphor® EL is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds. Due to its emulsification functionality, it finds application in biological membrane- based drug transport studies.

Other Notes

A derivative of castor oil and ethylene oxide.

Legal Information

Cremophor is a registered trademark of BASF SE
Kolliphor is a registered trademark of BASF

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


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Norepinephrine (NE) and angiotensin II (ANG II) are primary effectors of the sympathetic adrenergic and the renin-angiotensin-aldosterone systems, mediating hypertrophic, apoptotic, and fibrotic events in the myocardium. As NE and ANG II have been shown to affect intracellular calcium in

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