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C7821

Sigma-Aldrich

Curdlan from Alcaligenes faecalis

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Synonym(s):
β-1,3-Glucan hydrate
CAS Number:
MDL number:
NACRES:
NA.77

form

solid

Quality Level

storage temp.

2-8°C

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C1184C8546D8144
Curdlan from Alcaligenes faecalis

C7821

Curdlan from Alcaligenes faecalis

Cellulase from Aspergillus niger powder, ≥0.3 units/mg solid

C1184

Cellulase from Aspergillus niger

Dextranase from Penicillium sp. lyophilized powder, 400-800 units/mg protein

D8144

Dextranase from Penicillium sp.

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Curdlan is an insoluble natural polymer with linear structure mainly produced by Alcaligenes faecalis. It is a dietary fiber with gelatin properties.

Application

Curdlan from Alcaligenes faecalis has been used:
  • for the stimulation of carp macrophages for regulation of differentially expressed genes
  • to stimulate human intestinal epithelial cells for cytokine secretion
  • to study its effect on transcriptional responses of inflammation/respiratory burst-associated genes in mouse alveolar macrophages by customized reverse transcription (RT)-PCR based arrays
  • as a substrate in β-1,3–1,4-Glucanase activity assay

Biochem/physiol Actions

Curdlan is used as a food additive in the food industry. It improves the elasticity and reduces the embrittling tendency of hydroxyapatite/chitosan scaffold, which aids in bone regeneration.
Curdlan is a (1,3)-β-glucan. It is a pathogen-associated molecular-pattern (PAMP) recognized by the receptor dectin-1. Activation of dectin-1, together with TLR2/TLR6, promotes signaling resulting in the production of pro-inflammatory cytokines, thus inducing inflammation.

Preparation Note

For gelation at 70 °C, the concentration of the sodium hydroxide should be 0.01 M.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

Jing Li et al.
Applied microbiology and biotechnology, 97(19), 8495-8503 (2013-07-31)
Biologically active β-1,3-oligosaccharides with rapidly growing biomedical applications are produced from hydrolysis of curdlan polysaccharide. The water-insoluble curdlan impedes its hydrolysis efficiency which is enhanced by our newly developed alkali-neutralization treatment process to increase the stability of curdlan suspension to
Applications of natural polymer-based hydrogels in the food industry
"Handbook of Poylmer-Liquid Interaction Parameters and Solubility Parameters ", 357-410 (2020)
"Reference Module in Food Science (2020)
Characterisation of a novel Bacillus sp. SJ-10 I?-1,3-1,4-glucanase isolated from jeotgal, a traditional Korean fermented fish.
Kim, et al.
Bioprocess and Biosystems Engineering, 36, 721-727 (2013)
Microbial exopolisaccharides for biomedical applications
Journal of Material Science & Engineering, 165-219 (2019)

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