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C8180

Sigma-Aldrich

Cholera Toxin A Subunit from Vibrio cholerae

lyophilized powder

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MDL number:
NACRES:
NA.77

form

lyophilized powder

Quality Level

composition

Protein, ~5% Lowry

availability

not available in Japan

impurities

≤0.5% Cholera toxin B subunit (SDS-PAGE)

storage temp.

2-8°C

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This Item
C9903C3741C9972
storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

composition

Protein, ~5% Lowry

composition

Protein, ~5% Lowry

composition

-

composition

Protein, ~40% Lowry

availability

not available in Japan

availability

-

availability

-

availability

-

impurities

≤0.5% Cholera toxin B subunit (SDS-PAGE)

impurities

≤0.5% Cholera toxin A subunit (SDS-PAGE)

impurities

-

impurities

-

General description

Cholera Toxin (CT) is secreted by Vibrio cholerae. CT upregulates cell surface molecules, such as co-stimulatory molecules and chemokine receptors in antigen presenting cells(APCs), murine and human dendritic cells (DCs). It enhances the secretion of interleukin 1 (IL-1) from macrophages and stimulates their APC function. CT also functions as an immunomodulator. It is associated with watery diarrhoea, which is characteristic of cholera infection.

Application

Cholera Toxin A Subunit from Vibrio cholerae has been used as a specific probe for trimeric G proteins in membrane motility assays.

Biochem/physiol Actions

Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase

Physical form

Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA

Reconstitution

When reconstituted with 1 mL of water, the solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN3, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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