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C8198

Sigma-Aldrich

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit

whole antiserum

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Synonym(s):
CGRP Antibody - Anti-Calcitonin Gene Related Peptide antibody produced in rabbit, Cgrp Antibody, Anti-CGRP
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

rat

packaging

antibody small pack of 25 μL

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

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C7113C2581AB5705
antibody form

whole antiserum

antibody form

purified from hybridoma cell culture

antibody form

whole antiserum

antibody form

purified immunoglobulin

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

UniProt accession no.

P06881

UniProt accession no.

P01258

UniProt accession no.

P06307

UniProt accession no.

P01258

clone

polyclonal

clone

4901, monoclonal

clone

polyclonal

clone

polyclonal

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General description

Calcitonin Gene Related Peptide (CGRP), a cyclic peptide, belongs to a small family of peptides encoded by the calcitonin/CGRP gene complex. The calcitonin/CGRP gene complex consists of at least two genes, encoding for two forms of CGRP: -CGRP (CGRP-I) and -CGRP (CGRP-II). CGRP is synthesized and co-localized with calcitonin in the parafollicular C-cells of the thyroid gland and medullary thyroid carcinoma. It is principally considered a neuropeptide widely distributed in the central and peripheral nervous systems.

Specificity

Anti-Calcitonin Gene Related Peptide reacts with CGRP (rat). Cross-reactivity is observed with CGRP (human) and β-CGRP (human).

Immunogen

CGRP-KLH

Application

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit has been used in:
  • dot blot immunoassay
  • fluorescent labeling
  • confocal microscopy
  • immunohistofluorescence
  • epifluorescence imaging

Anti-Calcitonin Gene Related Peptide antibody produced in rabbit was used for immunohistochemistry of trigeminal ganglia cell cultures at a dilution of 1:200 and for immunocytochemistry of mouse lung slices at a dilution of 1:500.

Biochem/physiol Actions

CGRP is thought to act as a neurotransmitter or neuromodulator, particularly in the regulation of autonomic (e.g., cardiovascular, respiratory, gastrointestinal, taste, food intake and sleep) and limbic functions. CGRP is probably involved with substance P in mediating neurogenic inflammation and transmission of pain stimuli via the peripheral nervous system.
Calcitonin Gene Related Peptide is a G protein-coupled receptor that binds receptor-activity-modifying proteins (RAMP)1, -2 and -3. CLR has been implicated in conditions such as obesity, diabetes, osteoporosis, migraine and cardiovascular disease.

Quantity

delipidized

Physical form

Supplied as a liquid containing 0.1% sodium azide as a preservative

Storage and Stability

For continuous use, store 2-8°C. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free"freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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De-gang Yu et al.
Acta pharmacologica Sinica, 33(7), 924-934 (2012-05-23)
To investigate whether the stage of osteoarthritis (OA) progression influenced the efficacy of the third-generation bisphosphonate zoledronic acid in a rat medial meniscal tear model. Medial meniscal tear (MMT) was surgically induced in adult male Sprague Dawley rats. Zoledronic acid
Lina Almarestani et al.
Molecular pain, 4, 56-56 (2008-11-19)
Pain is a major symptom associated with chronic inflammation. In previous work from our laboratory, we have shown that in animal models of neuropathic pain there is a sprouting of sympathetic fibers into the upper dermis, a territory normally devoid
Kumiko Ishida et al.
Anesthesiology, 121(5), 1068-1079 (2014-07-06)
The aim of this study was to clarify the roles of calcitonin gene-related peptide (CGRP) in postoperative pain and inflammatory pain. αCGRP knockout mice that the authors have developed and wild-type mice were used. Pain behaviors were assessed after incision
Yae K Sugimura et al.
Journal of neurophysiology, 115(6), 2721-2739 (2016-02-19)
A large majority of neurons in the superficial layer of the dorsal horn projects to the lateral parabrachial nucleus (LPB). LPB neurons then project to the capsular part of the central amygdala (CeA; CeC), a key structure underlying the nociception-emotion
James Barwell et al.
British journal of pharmacology, 166(1), 51-65 (2011-06-09)
The calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR) are two of the 15 human family B (or Secretin-like) GPCRs. CTR and CLR are of considerable biological interest as their pharmacology is moulded by interactions with receptor activity-modifying proteins. They

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