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D5670

Sigma-Aldrich

Sodium deoxycholate monohydrate

BioXtra, ≥99.0% (titration)

Synonym(s):
3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt
Empirical Formula (Hill Notation):
C24H39NaO4 · H2O
CAS Number:
Molecular Weight:
432.57
Beilstein:
3643164
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

description

anionic

Quality Level

product line

BioXtra

Assay

≥99.0% (titration)

form

powder

optical activity

[α]20/D +44±2° in H2O(lit.)

mol wt

432.57 g/mol

technique(s)

electrophoresis: suitable
immunoprecipitation (IP): suitable

impurities

Insoluble matter, passes filter test
≤0.5% Cholic acid

pH

7.5-9.5 (20 °C, 0.1 M in H2O)

solubility

H2O: 0.1 M, clear, colorless

anion traces

sulfate (SO42-): ≤0.02%

cation traces

Al: ≤0.002%
Ba: ≤0.0005%
Bi: ≤0.0005%
Ca: ≤0.05%
Cd: ≤0.0005%
Co: ≤0.0005%
Cr: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.010%
Li: ≤0.0005%
Mg: ≤0.002%
Mn: ≤0.0005%
Mo: ≤0.0005%
Ni: ≤0.0005%
Pb: ≤0.0005%
Sr: ≤0.002%
Zn: ≤0.0005%

absorption

≤0.08 at 280 in H2O at 0.1 M
≤0.10 at 260 in H2O at 0.1 M

SMILES string

O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3CCC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C

InChI

1S/C24H40O4.Na.H2O/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);;1H2/q;+1;/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;;/m1../s1

InChI key

NDVHNZISGVSFMP-WTCAICSISA-M

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This Item
SRE00463097030968
Sodium deoxycholate Suitable for manufacturing of diagnostic kits and reagents

Sigma-Aldrich

SRE0046

Sodium deoxycholate

Sodium deoxycholate BioXtra, ≥98.0% (dry matter, NT)

Sigma-Aldrich

30970

Sodium deoxycholate

product line

BioXtra

product line

-

product line

BioXtra

product line

BioUltra

assay

≥99.0% (titration)

assay

≥98% (HPLC)

assay

≥98.0% (dry matter, NT)

assay

≥99.0% (NT)

form

powder

form

-

form

powder

form

powder

mol wt

432.57 g/mol

mol wt

micellar avg mol wt 1200-5000

mol wt

micellar avg mol wt 1200-5000

mol wt

average mol wt 1200-5000

technique(s)

electrophoresis: suitable, immunoprecipitation (IP): suitable

technique(s)

DNA purification: suitable, RNA purification: suitable, electrophoresis: suitable

technique(s)

DNA purification: suitable, RNA purification: suitable, electrophoresis: suitable

technique(s)

-

General description

Sodium deoxycholate (SDC) monohydrate is a bile acid salt.

Application

Sodium deoxycholate monohydrate has been used in a study to assess a method for the immobilization of lipoxygenase in an alginate-silicate gel matrix. It has also been used in a study to investigate the in vitro dissolution of gall stones.
Powerful solubilization agent; used in the solubilization of estrogen synthetase from human placental microsomes.

Biochem/physiol Actions

Bile Salt

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Effect of various lipid-bile salt mixed micelles on the intestinal absorption of amphotericin-B in rat
Dangi, J., et al.
Drug Devel. Ind. Pharm., 24, 631-631 (1998)
R P Modi et al.
Journal of the Indian Medical Association, 89(5), 129-132 (1991-05-01)
An in vitro study on dissolution of 36 gall-stones obtained from 3 patients (12 stones from each patient) was carried out in heparin, bile salt and clofibrate solutions of different strengths. Heparin was found to be a poor solvent while
Immobilization of lipoxygenase in an alginate-silicate solgel matrix: formation of fatty acid hydroperoxides
Hsu, A., et al.
Biotechnology Letters, 19, 71-71 (1997)
Liquid crystals and phase equilibria binary bile salt-water systems.
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Langmuir, 16(11), 5178-5186 (2000)
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During infection, Salmonella senses and responds to harsh environments within the host. Persistence in a bile-rich environment is important for Salmonella to infect the small intestine or gallbladder and the multidrug efflux system AcrAB-TolC is required for bile resistance. The

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