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D8946

Sigma-Aldrich

DMH1

≥98% (HPLC)

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Synonym(s):
4-[6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Empirical Formula (Hill Notation):
C24H20N4O
CAS Number:
Molecular Weight:
380.44
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

light yellow to orange

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3

InChI

1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3

InChI key

JMIFGARJSWXZSH-UHFFFAOYSA-N

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This Item
203646SML1535SML1832
DMH1 ≥98% (HPLC)

Sigma-Aldrich

D8946

DMH1

DMH2 ≥98% (HPLC)

Sigma-Aldrich

SML1535

DMH2

DDR1 Inhibitor 7rh ≥98% (HPLC)

Sigma-Aldrich

SML1832

DDR1 Inhibitor 7rh

form

powder

form

solid

form

powder

form

powder

storage condition

desiccated

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

-

color

light yellow to orange

color

orange

color

white to beige

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 16.6 mg/mL

solubility

DMSO: 1 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

DMH1 stimulates neurogenesis of human-induced pluripotent stem cells (hiPSCs) and suppresses the growth and metastasis of lung cancer. It blocks cellular autophagy responses.

Application

DMH1 has been used for bone morphogenetic protein (BMP) inhibition. It has also been used to block vascular endothelial growth factor (VEGF) signaling.

Biochem/physiol Actions

DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH1 is a dorsomorphin analogue that exclusively targets the BMP but not the VEGF pathway.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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