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F3385

Sigma-Aldrich

Fetuin from fetal bovine serum

lyophilized powder, BioReagent, suitable for cell culture

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Synonym(s):
Fetuin from fetal calf serum
CAS Number:
EC Number:
MDL number:
NACRES:
NA.75

product line

BioReagent

form

lyophilized powder

mol wt

48.4 kDa

technique(s)

cell culture | mammalian: suitable

impurities

≤0.3% free N-acetylneuraminic acid

solubility

H2O: 1 mg/mL

storage temp.

2-8°C

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This Item
F2379F3004F7942
Fetal Bovine Serum Canada origin, sterile-filtered, γ-irradiated, suitable for cell culture

Sigma-Aldrich

F7942

Fetal Bovine Serum

mol wt

48.4 kDa

mol wt

-

mol wt

-

mol wt

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, MALDI-MS: suitable

technique(s)

cell culture | mammalian: suitable

impurities

≤0.3% free N-acetylneuraminic acid

impurities

≤0.3% free N-acetylneuraminic acid

impurities

~0.2% free N-acetylneuraminic acid

impurities

≤10 EU/mL Endotoxin

solubility

H2O: 1 mg/mL

solubility

H2O: 1 mg/mL, colorless to faint yellow or tan

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

General description

Fetuin from fetal bovine serum is a plasma glycoprotein. It is a 64 kDa glycoprotein, which is produced by the liver and adipose tissue.
A glycoprotein derived from FBS that is used as Fetuin has been used at a concentration of 500 mg/ml to supplement serum free F12 medium (along with insulin, transferrin and 2-mercaptoethanol) in culture of embryonal carcinoma cells.

Application

Fetuin from fetal bovine serum has been used:
  • as a substrate to determine neuraminidase activity
  • to validate the specificity of sialidases
  • to stabilize m-calpain

Biochem/physiol Actions

Fetuin acts as an inhibitor of insulin receptor tyrosine kinase. It modulates bone remodeling and calcium metabolism. Fetuin regulates vascular calcification, insulin resistance, protease activity control, keratinocytes migration and breast tumor cell proliferative signaling. It functions as a biomarker for neurodegenerative diseases. Fetuin exhibits anti-inflammatory property.

Preparation Note

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Analyses of N-linked glycans of PrPSc revealed predominantly 2, 6-linked sialic acid residues
Katorcha E and Baskakov IV
FEBS Journal, 284(21), 3727-3738 (2017)
Fetuin A stabilizes m-calpain and facilitates plasma membrane repair
Mellgren RL and Huang X
The Journal of Biological Chemistry, 282(49), 35868-35877 (2007)
Antiviral activity of fermented ginseng extracts against a broad range of influenza viruses
Wang Y, et al.
Viruses, 10(9), 471-471 (2018)
Christopher Ashwood et al.
Journal of the American Society for Mass Spectrometry, 29(6), 1194-1209 (2018-04-01)
Profiling cellular protein glycosylation is challenging due to the presence of highly similar glycan structures that play diverse roles in cellular physiology. As the anomericity and the exact linkage type of a single glycosidic bond can influence glycan function, there
Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature
Dabrowska AM, et al.
Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 159(3), 352-359 (2015)

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