MilliporeSigma
All Photos(1)

Documents

F9552

Sigma-Aldrich

Formoterol fumarate dihydrate

>98% (HPLC)

Sign Into View Organizational & Contract Pricing

Synonym(s):
(R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate, Formoterol hemifumarate salt monohydrate
Empirical Formula (Hill Notation):
C19H24N2O4 · 0.5C4H4O4 · H2O
CAS Number:
Molecular Weight:
420.46
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

>98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: soluble 20 mg/mL
H2O: insoluble

originator

Novartis

SMILES string

O.O.OC(=O)\C=C\C(O)=O.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1.COc3ccc(C[C@H](C)NC[C@@H](O)c4ccc(O)c(NC=O)c4)cc3

InChI

1S/2C19H24N2O4.C4H4O4.2H2O/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8;;/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8);2*1H2/b;;2-1+;;/t2*13-,19+;;;/m00.../s1

InChI key

RATSWNOMCHFQGJ-TUYNVFRMSA-N

Gene Information

human ... ADRB2(154)

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
1286107F0372000B2185
vibrant-m

F9552

Formoterol fumarate dihydrate

vibrant-m

1286107

Formoterol fumarate

vibrant-m

F0372000

Formoterol fumarate dihydrate

vibrant-m

B2185

Bisoprolol hemifumarate salt

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

form

solid

form

-

form

-

form

solid

color

white to off-white

color

-

color

-

color

white

solubility

DMSO: soluble 20 mg/mL, H2O: insoluble

solubility

-

solubility

-

solubility

DMSO: >20 mg/mL

originator

Novartis

originator

-

originator

-

originator

Teva

Application

Formoterol fumarate dihydrate has been used:
  • as ß2-adrenergic agonist, to determine whether ß2-adrenergic receptor signaling was sufficient to induce up-regulation of select gene transcripts
  • as a ß2-adrenergic receptor agonist and a long term bronchodilator
  • as ß2-adrenergic receptor (ß2AR) agonist to recover renal function in ischemia-reperfusion injury (IRI) in mice

Biochem/physiol Actions

Formoterol fumarate dihydrate can be used along with budesonide to treat asthma.
β2-Adrenoreceptor agonist.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation markHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Repr. 2 - STOT RE 2 - STOT SE 1

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 6

1 of 6

Glycopyrronium bromide British Pharmacopoeia (BP) Reference Standard

BP1110

Glycopyrronium bromide

USP

USP

1078245

Budesonide Related Compound E

Glycopyrronium bromide European Pharmacopoeia (EP) Reference Standard

Y0001308

Glycopyrronium bromide

Glycopyrrolate ≥98% (HPLC)

Sigma-Aldrich

SML0029

Glycopyrrolate

beta-Adrenergic-stimulated macrophages: comprehensive localization in the M1-M2 spectrum
Lamkin D M, et al.
Brain, behavior, and immunity, 57(7), 338-346 (2016)
Proximal Tubule beta2 Adrenergic Receptor Mediates Formoterol-Induced Recovery of Mitochondrial and Renal Function After Ischemia-Reperfusion Injury.
Cameron R B, et al.
Journal of Pharmacology and Experimental Therapeutics, 31(10), 4335-4346 (2019)
Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma
Patel K R, et al.
Faseb Journal, 31(10), 4335-4346 (2017)
Budesonide+ formoterol fumarate dihydrate for the treatment of asthma
Wolthers O D
Expert Opinion on Pharmacotherapy, 17(7), 1023-1030 (2016)
Robert B Cameron et al.
The Journal of pharmacology and experimental therapeutics, 369(1), 173-180 (2019-02-03)
Acute kidney injury (AKI) is the rapid loss of renal function after an insult, and renal proximal tubule cells (RPTCs) are central to the pathogenesis of AKI. The β2-adrenergic receptor (β2AR) agonist formoterol accelerates the recovery of renal function in

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service