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G3643

Sigma-Aldrich

α1-Acid Glycoprotein from bovine plasma

≥99%

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Synonym(s):
Orosomucoid
CAS Number:
MDL number:
NACRES:
NA.61

biological source

bovine plasma

Quality Level

assay

≥99%

form

powder

technique(s)

electrophoresis: suitable
mass spectrometry (MS): suitable

UniProt accession no.

storage temp.

2-8°C

Gene Information

bovine ... ORM1(497200)

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This Item
G9885G0516112251
biological source

bovine plasma

biological source

human plasma

biological source

human plasma

biological source

human plasma

technique(s)

electrophoresis: suitable, mass spectrometry (MS): suitable

technique(s)

ELISA: suitable

technique(s)

electrophoresis: suitable

technique(s)

-

form

powder

form

powder

form

lyophilized powder

form

lyophilized

UniProt accession no.

Q3SZR3

UniProt accession no.

P02763

UniProt accession no.

P02765

UniProt accession no.

-

Gene Information

bovine ... ORM1(497200)

Gene Information

human ... ORM1(5004)

Gene Information

human ... AHSG(197)

Gene Information

-

General description

α1-Acid Glycoprotein (AGP, orosomucoid) from bovine plasma belongs to ‘lipocalins′ family which binds and transports small hydrophobic molecules. AGP is further classified into the subfamily ‘immunocalins′ which immunomodulates the inflammatory reactions. AGP is primarily produced in the liver, in few extra hepatic tissues and is present in neutrophil granules. Healthy cattle possesses 0.3 mg of AGP/ ml of concentrated serum.
α1-Acid glycoprotein (AGP, orosomucoid) is the major plasma glycoprotein with a molecular weight of 41-43 kDa. It is responsible for possessing the complex type of glycans.

Application

α1-Acid Glycoprotein (AGP) from bovine plasma has been used:
  • in mass spectrometry analysis to confirm the presence of Neu5Ac and Neu5Gc distribution in human and bovine AGP respectively
  • for pretreating the microvessel before perfusing the MDA-MB-231 cells for tumor adhesion studies
  • in the composition of tear model
  • as a reference in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)

α1-Acid glycoprotein was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine

Biochem/physiol Actions

α1-Acid Glycoprotein from bovine plasma is an acute phase protein. It has anti-inflammatory potential and its concentration increases several folds during injury. AGP increases the chemotactic activity and life span of monocytes and inhibits neutrophil degranulation. Serum AGP levels differentiates sepsis from systemic inflammatory response syndrome (SIRS).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

Slide 1 of 7

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alpha1-Acid glycoprotein modulates phagocytosis and killing of Escherichia coli by bovine polymorphonuclear leucocytes and monocytes
Lecchi C, et al.
The Veterinary Journal, 196(1), 47-51 (2013)
alpha-1-Acid glycoprotein as a biomarker for the early diagnosis and monitoring the prognosis of sepsis
Xiao K, et al.
Journal of Critical Care, 30(4), 744-751 (2015)
Adhesion of malignant mammary tumor cells MDA-MB-231 to microvessel wall increases microvascular permeability via degradation of endothelial surface glycocalyx
Cai B, et al.
Journal of Applied Physiology, 113(7), 1141-1153 (2012)
Identification of the bovine alpha1-acid glycoprotein in colostrum and milk
Ceciliani F, et al.
Veterninary Research, 36(5-6), 735-746 (2005)
Structure aided design of a Neu5Gc specific lectin
Day CJ, et al.
Scientific reports, 7(1), 1495-1495 (2017)

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