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G9137

Sigma-Aldrich

Gly-Pro 4-methoxy-β-naphthylamide

dipeptidylpeptidase IV substrate

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Synonym(s):
H-Gly-Pro-4MbNA
Empirical Formula (Hill Notation):
C18H21N3O3
CAS Number:
Molecular Weight:
327.38
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

COc1cc(NC(=O)C2CCCN2C(=O)CN)cc3ccccc13

InChI

1S/C18H21N3O3/c1-24-16-10-13(9-12-5-2-3-6-14(12)16)20-18(23)15-7-4-8-21(15)17(22)11-19/h2-3,5-6,9-10,15H,4,7-8,11,19H2,1H3,(H,20,23)

InChI key

LSZPYDQEJZWJIJ-UHFFFAOYSA-N

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G5261G2901G0142
vibrant-m

G9137

Gly-Pro 4-methoxy-β-naphthylamide

vibrant-m

G0142

Gly-Phe p-nitroanilide

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: 50 mg/mL, clear, colorless

solubility

1 M HCl: 50 mg/mL

solubility

DMF: 50 mg/mL, clear, yellow

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Application

Gly-Pro 4-methoxy-β-naphthylamide has been used as a substrate to evaluate the dipeptidyl peptidase-4 (DPP4) enzymatic activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

Substrate for Dipeptidyl Aminopeptidase IV

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Gerd Luippold et al.
Diabetes research and clinical practice, 143, 199-203 (2018-07-22)
The two dipeptidyl peptidase (DPP)-4 inhibitors, linagliptin and sitagliptin, were shown to exert different binding kinetics in vitro. Twenty-four hours after oral dosing particularly in vivo inhibition of renal-specific DPP-4 activity was more sustained in Sprague Dawley rats after exposure
Wesley Mah et al.
The American journal of pathology, 187(8), 1717-1735 (2017-06-24)
Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been
Wesley Mah et al.
The American journal of pathology, 187(8), 1717-1735 (2017-06-24)
Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been
Anna-Lena Mayer et al.
British journal of pharmacology, 178(4), 878-895 (2020-11-11)
Dipeptidyl peptidase 4 (DPP-4) inhibitors are a class of oral glucose-lowering drugs used in the treatment of type 2 diabetes. In a pilot study using human kidney biopsies, we observed high DPP-4 expression in early crescent formation. This glomerular lesion

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