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GS66

Sigma-Aldrich

GST M2-2, Recombinant Human

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Synonym(s):
GST4, GSTM, GTHMUS, glutathione S-transferase mu 2
NACRES:
NA.26

biological source

human

Quality Level

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

form

frozen liquid

specific activity

93.3 units/mg protein (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.)

mol wt

26 kDa

concentration

2.55 mg/mL

storage temp.

−70°C

Gene Information

human ... GSTM2(2946)

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GST O1-1, Recombinant Human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

concentration

2.55 mg/mL

concentration

1.52 mg/mL

concentration

3.1 mg/mL

concentration

1.98 mg/mL

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

mol wt

26 kDa

mol wt

23 kDa

mol wt

26 kDa

mol wt

26 kDa

Biochem/physiol Actions

Glutathione S-transferase mu 2 (GSTM2) is an enzyme that in humans is encoded by the GSTM2 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual′s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

Storage and Stability

The enzyme should be used by the end-user customer within 1 year of receipt.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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