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GS75

Sigma-Aldrich

GST O1-1, Recombinant Human

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Synonym(s):
GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
NACRES:
NA.26

biological source

human

Quality Level

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

form

frozen liquid

specific activity

4.21 units/mg protein (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature. )

mol wt

26 kDa

concentration

1.98 mg/mL

storage temp.

−70°C

Gene Information

human ... GSTO1(9446)

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GST M4-4, Recombinant Human

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in E. coli

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

concentration

1.98 mg/mL

concentration

1.52 mg/mL

concentration

1.01 mg/mL

concentration

1.8 mg/mL

mol wt

26 kDa

mol wt

23 kDa

mol wt

25 kDa

mol wt

26 kDa

form

frozen liquid

form

frozen liquid

form

frozen liquid

form

frozen liquid

Biochem/physiol Actions

Glutathione S-transferase omega 1 (GSTO1) is an enzyme that in humans is encoded by the GSTO1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.

Storage and Stability

The enzyme should be used by the end-user customer within 1 year of receipt.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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You-Tao Xu et al.
Scientific reports, 4, 6578-6578 (2014-10-11)
Glutathione S-transferase Omega (GSTO) plays an important role in the development of cancer. Recently, a number of studies have investigated the association between single nucleotide polymorphisms on GSTO and susceptibility to cancer; however, the results remain inconclusive. We performed a
Jein-Wen Chen et al.
Chemosphere, 88(4), 432-438 (2012-03-24)
Previous studies have shown that hair arsenic (As) levels are associated with an increased prevalence of metabolic syndrome (MetS), which is a strong predictor for type 2 diabetes. The objective of this study was to evaluate whether urinary arsenic methylation
Sara Piacentini et al.
Neuroscience letters, 506(2), 203-207 (2011-11-22)
Glutathione S-transferases are multifunctional enzymes involved in cellular detoxification. A genetic linkage was found between Alzheimer's Disease (AD) and the chromosome 10q, where the GSTO1 and GSTO2 genes are located, leading to the hypothesis that GST Omega class (GSTO) genes
Renato Polimanti et al.
Fertility and sterility, 101(3), 735-739 (2014-01-15)
To explore the role of the GSTO1 gene in the pathogenesis of recurrent miscarriage (RM). Genetic association study. Rome, Italy. 123 women with RM and 130 women without pregnancy complications. None. Genotyping of two single nucleotide polymorphisms (A140D and E208K)
Yang Li et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 10871-10877 (2014-08-03)
Esophageal squamous cell carcinoma (ESCC) is the main form of esophageal malignancy. The approach for early diagnosis of this malignancy is very limited. In the present study, we first evaluated glutathione S-transferase omega 1 (GSTO1), a protein related to metabolism

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