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GW21465

Sigma-Aldrich

Anti-PTPRC antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-CD45, Anti-LCA, Anti-Leukocyte common antigen
NACRES:
NA.41

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21465

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PTPRC(5788)

Immunogen

Immunogen Sequence: GI # 18641347, sequence 482-552
Recombinant protein tyrosine phosphatase, receptor type, C isoform 1

Application

Anti-PTPRC antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Protein tyrosine phosphatase, receptor type, C is an enzyme encoded by the PTPRC gene in humans. It is also known as CD45 antigen (CD stands for cluster of differentiation) and is originally called leukocyte common antigen (LCA). PTPRC acts as a binding receptor for galectin-3 and helps in inducing apoptosis of Jurkat cells. It plays a novel role on innate immune cells in promoting lymphopenia-induced T cell proliferation. The leukocyte-specific tyrosine phosphatase impacts T cell development and activation by modulating TCR signaling.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Jing Xue et al.
FEBS letters, 587(24), 3986-3994 (2013-11-12)
Galectin-3 has been reported to induce apoptosis of Jurkat cells through binding receptors such as CD45. CD45RABC is heavily O-glycosylated and N-glycosylated, while CD45RO is only N-glycosylated. In this study, no apoptosis induced by galectin-3 was detected in CD45RO-transfected cells
Amy E Saunders et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2831-2842 (2014-08-13)
The leukocyte-specific tyrosine phosphatase, CD45, severely impacts T cell development and activation by modulating TCR signaling. CD45-deficient (CD45KO) mice have reduced peripheral T cell numbers where CD8 T cells are underrepresented. In this article, we show that CD45KO mice are

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