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H1252

Sigma-Aldrich

Homovanillic acid

Fluorimetric reagent

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Synonym(s):
4-Hydroxy-3-methoxyphenylacetic acid, HVA
Linear Formula:
HOC6H3(OCH3)CH2CO2H
CAS Number:
Molecular Weight:
182.17
Beilstein/REAXYS Number:
2213447
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

assay

>99% (TLC)

form

powder

mp

142-145 °C (lit.)

solubility

ethanol: 50 mg/mL, colorless to light yellow

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

COc1cc(CC(O)=O)ccc1O

InChI

1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12)

InChI key

QRMZSPFSDQBLIX-UHFFFAOYSA-N

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This Item
C9008S9256N5625
vibrant-m

H1252

Homovanillic acid

vibrant-m

C9008

p-Coumaric acid

vibrant-m

S9256

Sulfanilic acid azochromotrop

vibrant-m

N5625

Naphthol AS phosphate

solubility

ethanol: 50 mg/mL, colorless to light yellow

solubility

ethanol: 50 mg/mL

solubility

water: 10 mg/mL

solubility

ethanol: 50 mg/mL, clear, light yellow

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

mp

142-145 °C (lit.)

mp

214 °C (dec.) (lit.)

mp

-

mp

-

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

−20°C

assay

>99% (TLC)

assay

≥98.0% (HPLC)

assay

≥80%

assay

>99% (TLC)

Application

Homovanillic acid has been used as a standard in HPLC analysis.

Biochem/physiol Actions

Metabolite of dihydroxyphenylacetic acid (DOPAC) by catechol O-methyltransferase; reagent for the fluorimetric determination of glucose oxidase and other oxidative enzymes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Practical Fluorescence (1990)
Forced nonuse in unilateral parkinsonian rats exacerbates injury.
Tillerson JL
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Tashjian AH and Armstrong EJ
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2011)
Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease.
Tillerson JL
Neuroscience, 119, 899-899 (2003)
Michèl A Willemsen et al.
Brain : a journal of neurology, 133(Pt 6), 1810-1822 (2010-05-01)
Tyrosine hydroxylase deficiency is an autosomal recessive disorder resulting from cerebral catecholamine deficiency. Tyrosine hydroxylase deficiency has been reported in fewer than 40 patients worldwide. To recapitulate all available evidence on clinical phenotypes and rational diagnostic and therapeutic approaches for

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