MilliporeSigma
All Photos(1)

Documents

H130

Sigma-Aldrich

R(+)-HA-966

solid

Sign Into View Organizational & Contract Pricing

Synonym(s):
R(+)-3-Amino-1-hydroxy-2-pyrrolidinone
Empirical Formula (Hill Notation):
C4H8N2O2
CAS Number:
Molecular Weight:
116.12
MDL number:
PubChem Substance ID:
NACRES:
NA.77

form

solid

Quality Level

optical activity

[α]22/D +103°, c = 1 in H2O(lit.)

color

white

solubility

H2O: soluble

SMILES string

N[C@@H]1CCN(O)C1=O

InChI

1S/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2/t3-/m1/s1

InChI key

HCKUBNLZMKAEIN-GSVOUGTGSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
H140P2371S179
R(+)-HA-966 solid

H130

R(+)-HA-966

(R)-(+)-8-Hydroxy-DPAT hydrobromide ≥98% (HPLC), solid

H140

(R)-(+)-8-Hydroxy-DPAT hydrobromide

Pamidronate disodium salt hydrate ≥95% (NMR), solid

P2371

Pamidronate disodium salt hydrate

R(+)-SKF-81297 hydrobromide ≥98% (HPLC), solid

S179

R(+)-SKF-81297 hydrobromide

solubility

H2O: soluble

solubility

H2O: >10 mg/mL at ±60 °C (with sonication)

solubility

H2O: 28 mg/mL

solubility

H2O: 6 mg/mL, DMSO: soluble

color

white

color

white to off-white

color

white

color

white to off-white

optical activity

[α]22/D +103°, c = 1 in H2O(lit.)

optical activity

[α]25/D +68.2°, c = 1 in methanol(lit.)

optical activity

-

optical activity

[α]22/D +15.14°, c = 0.52 in DMF(lit.)

Biochem/physiol Actions

Antagonist of the strychnine-insensitive glycine modulatory site associated with the NMDA receptor. More active enantiomer of (±)-HA-966.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

L Singh et al.
European journal of pharmacology, 186(1), 129-132 (1990-09-04)
Using a two-lever operant drug discrimination paradigm, rats have been trained to discriminate between the administration of saline and R-(+)-HA-966 (R-(+)-3-amino-1-hydroxypyrrolid-2-one, 30 mg/kg i.p.) an antagonist at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor/ion channel complex. Drug-appropriate responding
L Singh et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(1), 347-351 (1990-01-01)
The antagonist effect of (+/-)-3-amino-1-hydroxypyrrolid-2-one (HA-966) at the N-methyl-D-aspartate (NMDA) receptor occurs through a selective interaction with the glycine modulatory site within the receptor complex. When the enantiomers of (+/-)-HA-966 were resolved, the (R)-(+)-enantiomer was found to be a selective
L M Pullan et al.
Journal of neurochemistry, 55(4), 1346-1351 (1990-10-01)
HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is chiral. We report stereoselectivity for the (R)-enantiomer at the glycine antagonist site. In [3H]glycine binding, the (R)-enantiomer
Stephen L Carlson et al.
Brain and behavior, 2(4), 391-401 (2012-09-06)
D-Aspartate (D-Asp) activates a nonspecific cation current of unknown identity independent of L-glutamate (L-Glu) in neurons of Aplysia californica. Whole-cell voltage clamp studies were conducted using primary cultures of Aplysia buccal S cluster (BSC) neurons to characterize these receptor channels
Nicola Ferrari et al.
Nature communications, 10(1), 130-130 (2019-01-12)
Aggressive behaviours of solid tumours are highly influenced by the tumour microenvironment. Multiple signalling pathways can affect the normal function of stromal fibroblasts in tumours, but how these events are coordinated to generate tumour-promoting cancer-associated fibroblasts (CAFs) is not well understood. Here we

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service