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H3884

Sigma-Aldrich

Hyaluronidase from bovine testes

Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

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Synonym(s):
Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase
CAS Number:
Enzyme Commission number:
EC Number:
MDL number:

biological source

bovine testis

conjugate

conjugate (Glucosaminoglycan)

type

Type IV-S

form

lyophilized powder (essentially salt-free)

specific activity

750-3000 units/mg solid

mol wt

~55 kDa (four subunits of 14 kDa each)

UniProt accession no.

application(s)

diagnostic assay manufacturing

relevant disease(s)

cancer

storage temp.

−20°C

Gene Information

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1 of 4

This Item
H3631H3757H3506
vibrant-m

H3884

Hyaluronidase from bovine testes

vibrant-m

H3631

Hyaluronidase from bovine testes

vibrant-m

H3757

Hyaluronidase from bovine testes

vibrant-m

H3506

Hyaluronidase from bovine testes

biological source

bovine testis

biological source

bovine testis

biological source

bovine testis

biological source

-

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

Gene Information

-

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

~55 kDa (four subunits of 14 kDa each)

form

lyophilized powder (essentially salt-free)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

UniProt accession no.

Q5E985, Q8SQG8

UniProt accession no.

Q5E985, Q8SQG8

UniProt accession no.

Q5E985, Q8SQG8

UniProt accession no.

Q5E985, Q8SQG8

Biochem/physiol Actions

Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.

Unit Definition

One unit will degrade 0.75 μg of the polysaccharide hyaluronic acid per minute at pH 5.35 at 37 ºC (as measured by turbidimetric absorbance (λ: 600nm) when complexed with BSA after 45 minutes).

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Articles

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Protocols

This procedure may be used for Hyaluronidase products.

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