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H6501

Sigma-Aldrich

DL-β-Hydroxybutyric acid sodium salt

~98%

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Synonym(s):
(±)-3-Hydroxybutanoic acid sodium salt
Linear Formula:
C4H7O3Na
CAS Number:
Molecular Weight:
126.09
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.83

Assay

~98%

Quality Level

form

powder

solubility

water: 1 g/10 mL, clear, colorless

storage temp.

2-8°C

SMILES string

[Na].CC(O)CC(O)=O

InChI

1S/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1

InChI key

NBPUSGBJDWCHKC-UHFFFAOYSA-M

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This Item
K1875221511C4945
Sodium cacodylate trihydrate BioXtra, ≥98%

Sigma-Aldrich

C4945

Sodium cacodylate trihydrate

Premium Grade
form

powder

form

powder

form

solid

form

powder

solubility

water: 1 g/10 mL, clear, colorless

solubility

water: 100 mg/mL, clear, colorless

solubility

water: 1 g/10 mL, clear to slightly hazy, colorless

solubility

H2O: 0.5 M, clear, colorless

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

room temp

Application

DL-β-Hydroxybutyric acid sodium salt has been used:
  • as a standard for quantifying blood plasma and milk β-hydroxybutyric acid in Danish Jersey cows
  • to investigate its anticonvulsant effects in epilepsy induced rats
  • to induce hyperketonemia in Holstein dairy cows

Biochem/physiol Actions

β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Influence of DL-beta-hydroxybutyric acid on cell proliferation and calcium influx
Cheng S, et al.
Biomacromolecules, 6(2), 593-597 (2005)
Nikolaj Rittig et al.
Shock (Augusta, Ga.), 44(1), 32-35 (2015-04-22)
Endotoxin administrations are used in experimental models of inflammatory disease. Short-term endotoxin tolerance in response to repeated endotoxin exposure is well known, but the duration of endotoxin tolerance in humans remains unknown. The main purpose of this study was to
Fluorometric determination of beta-hydroxybutyrate in milk and blood plasma
Larsen T and Nielsen NI
Journal of Dairy Science, 88(6), 2004-2009 (2005)
Gwinyai E Chibisa et al.
Journal of animal science, 98(6) (2020-05-25)
Cattle need physically effective fiber to promote rumination and maintain rumen health, but economics favor the use of low-roughage feedlot diets. The study investigated the optimum barley silage proportion in barley-based finishing diets. Apparent total-tract digestibility (4-d total fecal collection)
Jianping Si et al.
Experimental and therapeutic medicine, 14(1), 765-770 (2017-07-05)
The present study aimed to investigate the anticonvulsant effects of β-hydroxybutyrate (BHB) in a kainic acid (KA)-induced rat seizure model. The concentrations of BHB and glucose were detected in the blood prior to exogenous BHB administration. Three different doses of

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