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Anti-TXN2 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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Anti-MTRX antibody produced in rabbit, Anti-Mt-Trx antibody produced in rabbit, Anti-Thioredoxin, mitochondrial precursor antibody produced in rabbit, Anti-Thioredoxin-2 antibody produced in rabbit
MDL number:
Human Protein Atlas Number:

biological source


Quality Level



antibody form

affinity isolated antibody

antibody product type

primary antibodies



product line

Prestige Antibodies® Powered by Atlas Antibodies


buffered aqueous glycerol solution

species reactivity



immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:200-1:500

immunogen sequence


UniProt accession no.

shipped in

wet ice

storage temp.


target post-translational modification


Gene Information

human ... TXN2(25828)

General description

The gene TXN2 (Thioredoxin 2) is mapped to human chromosome 22q13.1. The encoded protein is 166-amino acids long containing a mitochondria localization sequence at the N-terminal. It also contains a conserved thioredoxin active site and has a molar mass of 18kDa. It is predominantly expressed in heart, muscle, kidney, and adrenal gland.


Thioredoxin, mitochondrial precursor recombinant protein epitope signature tag (PrEST)


Anti-TXN2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit

Biochem/physiol Actions

Thioredoxin, mitochondrial is a protein encoded by the TXN2 gene in humans. Thioredoxin 2 is a small redox protein that plays an important role in cellular antioxidant defenses, as well as in the regulation of apoptosis. It possesses a dithiol-reducing enzymatic activity with mammalian thioredoxin reductase and NADPH. It is resistant to oxidation when compared to Trx1. It interacts with specific components of the mitochondrial respiratory chain and plays a crutial role in the regulation of the mitochondrial membrane potential. TXN2 is expressed in mitochondria and may directly protect it by preventing depolarization. Thioredoxin 2 interacts with mitochondrial transcription factor A (mtTFA) and facilitates its binding to damaged DNA. It also functions as an antioxidant.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.


Corresponding Antigen APREST73391

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids




Not applicable


Not applicable


Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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G Spyrou et al.
The Journal of biological chemistry, 272(5), 2936-2941 (1997-01-31)
We have isolated a 1276-base pair cDNA from a rat heart cDNA library that encodes a novel thioredoxin (Trx2) of 166 amino acid residues with a calculated molecular mass of 18.2 kDa. Trx2 possesses the conserved thioredoxin-active site, Trp-Cys-Gly-Pro-Cys, but
Shu Wen et al.
American journal of medical genetics. Part A, 149A(2), 155-160 (2009-01-24)
TXN2 encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Txn2 knockout mice fail to complete neural tube closure by E10.5 and die in utero. We hypothesized that
Akihiko Kidani et al.
International journal of oncology, 35(6), 1435-1440 (2009-11-04)
Mitochondrial transcription factor A (mtTFA) is a member of the HMG (high mobility group)-box protein family. We previously showed that mtTFA preferentially binds to both cisplatin-damaged and oxidatively damaged DNA. In this study, we found that expression levels of both
Anastasios E Damdimopoulos et al.
The Journal of biological chemistry, 277(36), 33249-33257 (2002-06-25)
Thioredoxins (Trx) are a class of small multifunctional redox-active proteins found in all organisms. Recently, we reported the cloning of a mitochondrial thioredoxin, Trx2, from rat heart. To investigate the biological role of Trx2 we have isolated the human homologue
Eliska Holzerova et al.
Brain : a journal of neurology, 139(Pt 2), 346-354 (2015-12-03)
Thioredoxin 2 (TXN2; also known as Trx2) is a small mitochondrial redox protein essential for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Exome sequencing in a 16-year-old adolescent suffering from an infantile-onset neurodegenerative disorder

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