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HPA038515

Sigma-Aldrich

Anti-PRG2 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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Synonym(s):
Anti-BMPG, Anti-MBP, Anti-Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:500-1:1000

immunogen sequence

GSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRRC

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PRG2(5553)

General description

PRG2 (proteoglycan 2, pro eosinophil major basic protein)/ major basic protein (MBP) is a cationic protein of human eosinophil specific granules, that is present in crystalloid cores of these granules. MBP is a helminthotoxin. PRG2 is mapped to human chromosome 11q12.

Immunogen

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-PRG2 antibody produced in rabbit has been used in immunohistochemistry.

Biochem/physiol Actions

Eosinophils are white blood cells, which play a major role in innate immunity and in the pathogenesis of several inflammatory and neoplastic disorders. Accumulation of PRG2 (proteoglycan 2, pro eosinophil major basic protein)/ major basic protein (MBP) impairs epithelial cells in vitro, in vivo and ex vivo. It plays an important role in mediating cytotoxicity and allergic disorders like asthma. PRG2 helps to enhance smooth muscle reactivity by affecting vagal muscarinic M2 receptor, that helps in the progression of airway hyperreactivity.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST80814

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

wgk_germany

WGK 1


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Functional copy number changes in Sezary syndrome: toward an integrated molecular cytogenetic map III.
Mao X and McElwaine S
Cancer Genetics and Cytogenetics, 185(2), 86-94 (2008)
Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells.
Seebauer CT, et al.
Oncoimmunology, 5(12), e1242543-e1242543 (2016)
Elisa T Zhang et al.
Biology of reproduction, 105(1), 244-257 (2021-05-14)
The obstetrical conditions placenta accreta spectrum (PAS) and placenta previa are a significant source of pregnancy-associated morbidity and mortality, yet the specific molecular and cellular underpinnings of these conditions are not known. In this study, we identified misregulated gene expression
Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.
Soragni A, et al.
Molecular Cell, 57(6), 1011-1021 (2015)
Vesicle-mediated secretion of human eosinophil granule-derived major basic protein.
Melo RCN, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 89(7), 769-769 (2009)

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