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I1142

Sigma-Aldrich

Monoclonal Anti-Interferon-γ antibody produced in rat

clone 37895, purified immunoglobulin, lyophilized powder

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Synonym(s):
Anti-IFN-γ
MDL number:
NACRES:
NA.41

biological source

rat

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

37895, monoclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

flow cytometry: suitable
neutralization: suitable
western blot: suitable

isotype

IgG2a

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Ifng(15978)

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This Item
I5521I9016SAB4700340
conjugate

unconjugated

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

Gene Information

mouse ... Ifng(15978)

Gene Information

human ... IFNG(3458)

Gene Information

human ... IFNG(3458)

Gene Information

human ... IFNG(3458)

clone

37895, monoclonal

clone

25718, monoclonal

clone

polyclonal

clone

G-23, monoclonal

biological source

rat

biological source

mouse

biological source

goat

biological source

mouse

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

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General description

Interferon-γ (IFN-γ) belongs to Type II class of interferons and is produced by T helper cells (specifically, Th1 cells), natural killer (NK) and natural killer T (NKT) cells and cytotoxic T cells (TC cells) . It has various biological functions including antiviral activity like inhibition of cell or tumor growth, act as a potent modulator of immune responses and modifies cellular processes as well as stimulates the differentiation of B cells into immunoglobulin-producing cells. Monoclonal Anti-Interferon-γ antibody can be used in immunoblotting. Rat anti-Interferon-γ antibody has shown no cross-reactivity for recombinant human IFN-γ or recombinant rat IFN-γ.

Specificity

The antibody does not cross-react with recombinat human IFN-γ or recombinant rat IFN-γ.

Immunogen

recombinant mouse IFN-γ.

Application

Monoclonal Anti-Interferon-γ antibody can be used in neutralization and indirect ELISA.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline and 5% trehalose.

Preparation Note

Purified from cell culture supernatant using protein G.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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I Gresser et al.
Proceedings of the National Academy of Sciences of the United States of America, 66(4), 1052-1058 (1970-08-01)
Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells in stationary suspension cultures. The degree of inhibition was found to correlate with the antiviral titer of the interferon preparations. The factor(s) responsible for inhibition of L 1210
P B Fisher et al.
Pharmacology & therapeutics, 27(2), 143-166 (1985-01-01)
As described in this review, both partially purified and recombinant interferons are potent modulators of differentiation in diverse cell culture systems (Table 2). Depending on the target cell, interferon exerts either an inhibitory or an inductive effect on cell differentiation.
J Vilcek et al.
Journal of immunology (Baltimore, Md. : 1950), 135(3), 1851-1856 (1985-09-01)
Interferon (IFN)-gamma production, stimulated by the addition of exogenous interleukin (IL) 2, T cell mitogens, or tuberculin purified protein derivative (PPD) was studied in cultures of separated human mononuclear cells or unseparated peripheral blood leukocytes (PBL). IFN-gamma was induced by
P D Benech et al.
The Journal of experimental medicine, 176(4), 1115-1123 (1992-10-01)
The human Fc gamma RI (CD64) is a high affinity receptor for the Fc portion of immunoglobulin (Ig), and its constitutively low expression on the cell surface of monocyte/macrophage and neutrophils is selectively upregulated by interferon gamma (IFN-gamma) treatment (Perussia
Jamie R Schoenborn et al.
Advances in immunology, 96, 41-101 (2007-11-06)
Interferon-gamma (IFN-gamma) is crucial for immunity against intracellular pathogens and for tumor control. However, aberrant IFN-gamma expression has been associated with a number of autoinflammatory and autoimmune diseases. This cytokine is produced predominantly by natural killer (NK) and natural killer

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