MilliporeSigma
All Photos(1)

Documents

I4028

Sigma-Aldrich

Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

clone 70625.111, purified immunoglobulin, lyophilized powder

Sign Into View Organizational & Contract Pricing

Synonym(s):
Anti-IL-18 Receptor
MDL number:
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

70625.111, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: suitable (2.5μg/SUP>106 cell)
immunocytochemistry: 8-25 μg/mL
immunohistochemistry: 8-25 μg/mL

isotype

IgG1

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL18R1(8809)

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
WH0008809M1I3642I6909
species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

Gene Information

human ... IL18R1(8809)

Gene Information

human ... IL18R1(8809)

Gene Information

human ... IL1B(3553)

Gene Information

human ... IL2(3558)

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

clone

70625.111, monoclonal

clone

3C8, monoclonal

clone

8516.311, monoclonal

clone

5355, monoclonal

Still not finding the right product?  

Give our Product Selector Tool a try.

General description

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

Immunogen

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

Biochem/physiol Actions

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using protein G.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Diana Boraschi et al.
European cytokine network, 17(4), 224-252 (2007-03-14)
IL-18 is among the cytokines responsible for immune-mediated pathologies and is probably one of the factors that contribute to the pathogenesis of autoimmune diseases. Identification of the causes of uncontrolled IL-18 production and activity in autoimmunity would allow for novel
J Alastair Gracie et al.
Journal of leukocyte biology, 73(2), 213-224 (2003-01-30)
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service