MAGI-2 is composed of three domains including six PDZ, one guanylate kinase (GK) and two WW domain.

The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.²

MAGI-2 was initially identified in rat, as a protein interacting with N-methyl-D-aspartate receptors (NMDA-R) and neuronal cell adhesion proteins, and was named S-SCAM.⁴Three isoforms of S-SCAM were identified, of 1277, 1113 and 1053 amino acids length, respectively.⁵

synthetic peptide corresponding to amino acids 554-571 of MAGI-2/S-SCAM conjugated to KLH.

Anti-MAGI-2 antibody produced in rabbit has been used in immunoblotting and immunolabeling.

Membrane associated guanylate kinase inverted-2 (MAGI-2) as well as MAGI-3, was shown to interact with the tumor suppressor PTEN through one of its PDZ domains, apparently acting as a scaffolding protein that could assemble a multi subunit signaling complex. It is known to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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