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M6034

Sigma-Aldrich

IgG2a, Lambda from murine myeloma

clone HOPC-1, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Mouse IgG2a-λ
MDL number:
NACRES:
NA.46

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

clone

HOPC-1, monoclonal

form

buffered aqueous solution

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

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I3784M9035I5404
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

HOPC-1, monoclonal

clone

DX, monoclonal

clone

MOPC 31C, monoclonal

clone

-

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

-

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

An immunoglobulin has two heavy chain and two light chain connected by disulfide bond. It is a glycoprotein. Rat has five immunoglobulin classes- IgM, IgG, IgA, IgD and IgGE. Immunoglobulin G (IgG) is a major class of immunoglobulin. IgG has four subclasses- IgG1, IgG2a, IgG2b and IgG2c.
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections
IgG2a, λ from murine myeloma specifically recognizes mouse IgG2a. Specificity of the mouse IgG2a, λ is determined by immunodiffusion and IEP techniques. The purified myeloma preparation is non-reactive with antisera to mouse IgA, IgM, IgG1, IgG2a, IgG2b and IgG3.

Application

IgG2a, Lambda from murine myeloma has been used to standardize the enzyme-linked immunosorbent assay (ELISA) assay.

Biochem/physiol Actions

Immunoglobulin G (IgG) mainly helps in immune defense. Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.

Physical form

Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Molecular Genetics of Immunoglobulin, 17 (1987)
The Immunoglobulins: Structure and Function (1998)
The Laboratory Rat (1998)
M Motta et al.
Leukemia, 19(10), 1788-1793 (2005-08-12)
Patients with chronic lymphocytic leukemia (CLL) have defects in both cellular and humoral immunity. Since CD152 (CTLA-4) plays a critical role in downregulating T-cell responses, we studied the expression of surface and cytoplasmic CD152 (sCD152 and cCD152, respectively) in freshly
A human immunoglobulin lambda locus is similarly well expressed in mice and humans
Popov AV, et al.
The Journal of Experimental Medicine, 189(10), 1611-1620 (1999)

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