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M8819

Sigma-Aldrich

Mannide monooleate

from plant

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About This Item

CAS Number:
9049-98-3
MDL number:
MFCD03840565
UNSPSC Code:
12352201
PubChem Substance ID:
329818072
NACRES:
NA.25

biological source

plant

form

liquid

color

dark brown

storage temp.

room temp

SMILES string

CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O

InChI

1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/b10-9-/t20-,21+,23+,24+/m0/s1

InChI key

NWGKJDSIEKMTRX-AAZCQSIUSA-N

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General description

Mannide monooleate is a lipohilic surfactant. It is also a non-ionic surface active emulsifier.

Application

Mannide monooleate has been used in a study to assess Freund′s incomplete adjuvant emulsion system, which is used in vaccine therapy. It has also been used in a study to investigate the metabolic fate of mineral oil adjuvants using 14C-labeled tracers.

Biochem/physiol Actions

Mannide monooleate is an emulsifying agent utilized in Freund′s incomplete adjuvant, although reactogenicity is an issue with human use.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Metabolic fate of mineral oil adjuvants using 14C-labeled tracers. II. Mannide monooleate.
J N Bollinger
Journal of pharmaceutical sciences, 59(8), 1088-1092 (1970-08-01)
R O Williams et al.
Drug development and industrial pharmacy, 24(2), 157-162 (2004-12-21)
Freund's Incomplete Adjuvant (FIA), which is used in vaccine therapy, is a water-in-oil emulsion delivery system consisting of an aqueous internal phase containing an antigenic protein dispersed in an external phase containing a mixture of mannide monooleate and light mineral
Jerome Aucouturier et al.
Expert review of vaccines, 1(1), 111-118 (2003-08-12)
The development of adjuvants will represent a major challenge for this century. Indeed the need for safer vaccines leads to the development of a new generation of antigens like synthetic peptide, recombinant proteins or even vectored DNA. However, this is
Marco Tamborrini et al.
Malaria journal, 10, 359-359 (2011-12-15)
In clinical trials, immunopotentiating reconstituted influenza virosomes (IRIVs) have shown great potential as a versatile antigen delivery platform for synthetic peptides derived from Plasmodium falciparum antigens. This study describes the immunogenicity of a virosomally-formulated recombinant fusion protein comprising domains of
Alexander D Douglas et al.
Vaccine, 28(44), 7167-7178 (2010-10-13)
Subunit vaccination modalities tend to induce particular immune effector responses. Viral vectors are well known for their ability to induce strong T cell responses, while protein-adjuvant vaccines have been used primarily for induction of antibody responses. Here, we demonstrate in
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