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P3351

Millipore

Protein L–Agarose from Peptostreptococcus magnus

recombinant, expressed in E. coli

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NACRES:
NA.56

recombinant

expressed in E. coli

Quality Level

matrix

6% beaded agarose supplied as 50% slurry

matrix activation

cyanogen bromide

matrix attachment

amino

capacity

3-10 mg/mL binding capacity

storage temp.

2-8°C

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This Item
P5906P2545P3101
Millipore

P2545

Protein A–Agarose

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

matrix

6% beaded agarose supplied as 50% slurry

matrix

Cross-linked 4% beaded agarose

matrix

-

matrix

-

matrix activation

cyanogen bromide

matrix activation

cyanogen bromide

matrix activation

cyanogen bromide

matrix activation

-

matrix attachment

amino

matrix attachment

amino

matrix attachment

amino

matrix attachment

-

capacity

3-10 mg/mL binding capacity

capacity

≥20 mg/mL (Human IgG)

capacity

≥15 mg/mL binding capacity (human IgG)

capacity

-

Application

Protein L-agarose is used in affinity chromatography, protein chromatography, antibody purification and characterization, immunoaffinity matrices, phosphorylation analysis, and protein A, G and L resins. Protein L-agarose has been used to provide evidence that antineuronal antibodies may contribute to neuronal dysfunction observed in a subset of patients with neurogenic chronic intestinal pseudoobstruction. Protein L agarose has also been used to evaluate a diabody to improve protection againse a potent scorpion neurotoxin.
Protein L from Peptostreptococcus magnus binds immunoglobulins (Ig) primarily through kappa light chain interactions without interfering with the antigen binding site. Recombinant Protein L contains four Ig-binding domains.

Preparation Note

Prepared with recombinant Peptostreptococcus magnus Protein L.

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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25G
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Pregnancy-associated malaria (PAM) is associated with the massive sequestration of erythrocytes infected with CSA-binding parasites in the placenta. Natural protective immunity against PAM is acquired during the course of pregnancies, with the development of anti-PfEMP1 antibodies recognizing placental infected erythrocytes
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Diabodies are recombinant, dimeric, antibody-based molecules composed of two non-covalently associated single-chain antibody fragments that bind to an antigen in a divalent manner. In an attempt to develop more effective therapeutic molecules against scorpion venoms, we designed a diabody derived
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This work investigated the adsorption of autoantibodies such as anti-SS-A/Ro, anti-SS-B/La, anti-Sm, and anti-dsDNA on protein L-agarose gel. In order to determine better conditions for IgG adsorption on this matrix, some buffer systems were tested. Adsorption data were analyzed using
Roberto de Giorgio et al.
Gastroenterology, 135(2), 601-609 (2008-06-28)
Activation of autoimmune pathways has been implicated as a contributing mechanism to the pathophysiology in some patients with chronic intestinal pseudoobstruction (CIP). In this study we tested the hypothesis that sera from a subpopulation of patients with CIP contain autoantibodies

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