P5396

Phosphomycin disodium salt

antibacterial MurA inhibitor

• Synonym(s): (−)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, Fosfomycin, Phosphonomycin
• Empirical Formula (Hill Notation): C₃H₅Na₂O₄P
• Molecular Weight: 182.02
• Beilstein/REAXYS Number: 4604425
• EC Number: 247-409-2
• MDL number: MFCD22741288
• UNSPSC Code: 51102829
• PubChem Substance ID: 24278640
• NACRES: NA.85

Properties

• Quality Level: 200
• form: powder
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [Na+].[Na+].C[C@@H]1O[C@@H]1P([O-])([O-])=O
• InChI: 1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1
• InChI key: QZIQJIKUVJMTDG-JSTPYPERSA-L

Description

Application

Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine.

Biochem/physiol Actions

Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.

Other Notes

1g,5g,50g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)