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Key Documents

PZ0270

Sigma-Aldrich

PF-05190457

≥95% (HPLC)

Synonym(s):

1-[2-[(1R)-2,3-Dihydro-5-(6-methyl-4-pyrimidinyl)-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-ethanone, 2-(2-Methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-ylethanone, PF 5190457, PF-5190457

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About This Item

Empirical Formula (Hill Notation):
C29H32N6OS
CAS Number:
Molecular Weight:
512.67
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:

Quality Level

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D +40 to +60°, c = 0.5 in methanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

CC1=CN2C(S1)=NC(CC(N3CCC4(CN([C@H](CCC5=C6)C5=CC=C6C7=NC=NC(C)=C7)C4)CC3)=O)=C2

InChI

1S/C29H32N6OS/c1-19-11-25(31-18-30-19)22-3-5-24-21(12-22)4-6-26(24)35-16-29(17-35)7-9-33(10-8-29)27(36)13-23-15-34-14-20(2)37-28(34)32-23/h3,5,11-12,14-15,18,26H,4,6-10,13,16-17H2,1-2H3/t26-/m1/s1

InChI key

ZIUDADZJCKGWKR-AREMUKBSSA-N

Biochem/physiol Actions

PF-05190457 is an orally available, potent and selective ghrelin receptor inverse agonist. PF-05190457 potently increases insulin secretion in glucose-stimulated human islets.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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