R136

Ro 31-8220 methanesulfonate salt

solid

• Synonym(s): 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate salt, Bisindoylmaleimidine IX
• Linear Formula: C₂₅H₂₃N₅O₂S · CH₃SO₃H
• CAS Number: 138489-18-6
• Molecular Weight: 553.65
• MDL number: MFCD03788207
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824000
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• assay: ≥98% (HPLC)
• form: solid
• color: orange to red
• solubility: H₂O: 7.3 mg/mL
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCSC(N)=N)c4ccccc34)c5ccccc15
• InChI: 1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4)
• InChI key: SAWVGDJBSPLRRB-UHFFFAOYSA-N

Description

General description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GRKs, GSK-3, MAPKAPs and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Photosensitive

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)