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RAB1378

Sigma-Aldrich

Human CMG-2 ELISA

for serum, plasma and cell culture supernatants

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NACRES:
NA.32

species reactivity

human

technique(s)

ELISA: suitable

input

sample type serum
sample type plasma
sample type cell culture supernatant(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... ANTXR2(118429)

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technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

input

sample type serum
sample type plasma
sample type cell culture supernatant(s)

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum

input

sample type plasma
sample type serum
sample type cell culture supernatant(s)

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum sample(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%

assay range

inter-assay cv: <12%
intra-assay cv: <10%

assay range

inter-assay cv: <12%
intra-assay cv: <10%

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1.6 ng/ml

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Anthrax toxin receptor (ANTXR2), also known as capillary morphogenesis protein gene-2 (CMG2), is encoded by the gene mapped to human chromosome 24q21. CMG2 is a ubiquitously expressed type I transmembrane protein. It contains von Willebrand A (vWA) domain that is involved in binding lamin and collagen IV.
This ELISA antibody pair detects Human CMG-2. Other species not yet determined.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Anthrax toxin receptor (ANTXR2)/ capillary morphogenesis protein gene-2 (CMG2) has been implicated in basement-membrane matrix assembly and endothelial cell morphogenesis. CMG2 acts as a chief receptor for anthrax in vivo. It stimulates the anthrax toxin activity by equipping toxin with a high-affinity binding anchor on the cell membrane and a path of entry into the host cell. Mutation in the gene is associated with the development of rare, autosomal recessive disorders called, Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH).

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Systemic hyalinosis with heterozygous CMG2 mutations: a case report and review of literature.
Rahvar M, et al.
The American Journal of Dermatopathology, 38(5), e60-e63 (2016)
Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation
Sun J, et al.
Toxins, 8(2), 34-34 (2016)
Identification of 2 Novel ANTXR2 Mutations in Patients With Hyaline Fibromatosis Syndrome and Proposal of a Modified Grading System
Denadai R, et al.
American Journal of Medical Genetics. Part A, 158(4), 732-742 (2012)

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