S8648
Somatotropin (STH) from porcine pituitary
Synonym(s):
Growth Hormone
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About This Item
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sterility
non-sterile
Quality Level
form
powder
mol wt
~22 kDa
packaging
vial of ~50 IU
drug control
Home Office Schedule 4.2
solubility
ethanolamine: 5 mg/mL (basic buffers, pH 9-10)
UniProt accession no.
shipped in
ambient
storage temp.
2-8°C
Gene Information
pig ... GH(396884)
Amino Acid Sequence
Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Ala-Asn-Ala-Val-Leu-Arg-Ala-Gln-His-Leu-His-Gln-Leu-Ala-Ala-Asp-Thr-Tyr-Lys-Glu-Phe-Glu-Arg-Ala-Tyr-Ile-Pro-Glu-Gly-Gln-Arg-Tyr-Ser-Ile-Gln-Asn-Ala-Gln-Ala-Ala-Phe-Cys-Phe-Ser-Glu-Thr-Ile-Pro-Ala-Pro-Thr-Gly-Lys-Asp-Glu-Ala-Gln-Gln-Arg-Ser-Asp-Val-Glu-Leu-Leu-Arg-Phe-Ser-Leu-Leu-Leu-Ile-Gln-Ser-Trp-Leu-Gly-Pro-Val-Gln-Phe-Leu-Ser-Arg-Val-Phe-Thr-Asn-Ser-Leu-Val-Phe-Gly-Thr-Ser-Asp-Arg-Val-Tyr-Glu-Lys-Leu-Lys-Asp-Leu-Glu-Glu-Gly-Ile-Gln-Ala-Leu-Met-Arg-Glu-Leu-Glu-Asp-Gly-Ser-Pro-Arg-Ala-Gly-Gln-Ile-Leu-Lys-Gln-Thr-Tyr-Asp-Lys-Phe-Asp-Thr-Asn-Leu-Arg-Ser-Asp-Asp-Ala-Leu-Leu-Lys-Asn-Tyr-Gly-Leu-Leu-Ser-Cys-Phe-Lys-Lys-Asp-Leu-His-Lys-Ala-Glu-Thr-Tyr-Leu-Arg-Val-Met-Lys-Cys-Arg-Arg-Phe-Val-Glu-Ser-Ser-Cys-Ala-Phe
General description
Somatotropin or growth hormone is a peptide hormone that is secreted by the anterior pituitary gland. It is essential for growth. The hormone increases muscle mass, reduces fat mass, helps in maintaining normal blood glucose levels and also promotes a balanced lipid profile.
Application
Somatotropin (STH) has been used to study its effects on repressing hepatic H2S production post-transcriptionally. It has also been used as one of the components of a medium to culture primordial follicles.
Biochem/physiol Actions
Increases mass of most tissues by increasing cell number rather than cell size, mobilizes fat stores
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Busting myths about UK food production.
The Veterinary record, 172(13), 323-325 (2013-03-30)
[Case report ; a case of Bardet-Biedl syndrome with a pituitary tumor and growth hormone deficiency].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(3), 704-707 (2013-06-20)
The Veterinary clinics of North America. Small animal practice, 43(2), 319-350 (2013-03-26)
When confronted with a diabetic cat in clinical practice, it is tempting to assume it has a form of diabetes mellitus akin to human type 2 diabetes mellitus (diabetes). For most diabetic cats examined, this will indeed be justified. Nevertheless
Obesity: a somatotrope perspective.
Endocrinology, 154(4), 1390-1391 (2013-03-26)
Endocrinology, 154(7), 2410-2420 (2013-05-15)
IGF-I is considered a primary inhibitor of GH secretion. Insulin may also play an important role in regulating GH levels because insulin, like IGF-I, can suppress GH synthesis and release in primary pituitary cell cultures and insulin is negatively correlated
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