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SAB1300499

Sigma-Aldrich

Anti-PPM1E (N-term) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

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Synonym(s):
Anti-PP2C-eta, Anti-PP2CE, Anti-PPM1M, Anti-Protein phosphatase 1M, Protein phosphatase 2C isoform eta
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

saturated ammonium sulfate (SAS) precipitated

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: 1:1000
western blot: 1:100-1:500

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PPM1E(132160)

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SAB1300999SAB1411020SAB1300929
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

saturated ammonium sulfate (SAS) precipitated

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

antibody form

saturated ammonium sulfate (SAS) precipitated

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

technique(s)

indirect ELISA: 1:1000, western blot: 1:100-1:500

technique(s)

immunohistochemistry: 1:50-1:100, indirect ELISA: 1:1000

technique(s)

proximity ligation assay: suitable, western blot: 1 μg/mL

technique(s)

indirect ELISA: 1:1000, western blot: 1:100-1:500

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

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General description

PPM1M is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).

Immunogen

PPM1E (NP_653242, 7-38)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PPM1E.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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