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SAB1305535

Sigma-Aldrich

MONOCLONAL ANTI-MYC TAG antibody produced in mouse

clone 9E10, IgG fraction of antiserum, buffered aqueous solution

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Synonym(s):
Tag from c-Myc protein
NACRES:
NA.43

biological source

mouse

Quality Level

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

9E10, monoclonal

form

buffered aqueous solution

technique(s)

western blot: 1:2,000

isotype

IgG1

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

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C6594SAB4700447SAB2108476
vibrant-m

SAB2108476

Anti-MYC

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

clone

9E10, monoclonal

clone

9E10, monoclonal

clone

9E10, monoclonal

clone

polyclonal

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

technique(s)

western blot: 1:2,000

technique(s)

direct immunofluorescence: 1:50 using formalin-fixed, paraffin-embedded human colon carcinoma tissue

technique(s)

flow cytometry: suitable

technique(s)

immunoblotting: suitable, immunohistochemistry: suitable

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

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General description

The cellular myelocytomatosis (c-myc) gene is mapped to human chromosome 8q24. It is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. c-myc is a member of MYC gene family.c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor that regulates the G1-S cell cycle transition.

Application

MONOCLONAL ANTI-MYC TAG antibody produced in mouse has been used in Western blotting.

Biochem/physiol Actions

The cellular myelocytomatosis (c-myc) oncogene plays a vital role in cellular proliferation, differentiation, apoptosis and acts as transcriptional regulator of gene expression. c-myc expression is essential and sufficient to assist most of the cells to enter DNA synthetic (S) phase of the cell cycle. The encoded protein plays a crucial role in vasculogenesis and angiogenesis during cancer development and progression. c-myc interacts with its binding partner Max and activates the transcription of growth promoting genes such as cyclin D2 and ornithine decarboxylase. It also represses the transcription of multiple genes, especially p21 and p27, by binding to the transcription initiator element (Inr) in a complex with Max and either Sp1 or Miz1. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in poor outcome and invasive treatment when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP).

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jung-Soon Mo et al.
PloS one, 7(5), e37111-e37111 (2012-05-17)
The gamma-secretase complex is involved in the intramembranous proteolysis of a variety of substrates, including the amyloid precursor protein and the Notch receptor. Nicastrin (NCT) is an essential component of the gamma-secretase complex and functions as a receptor for gamma-secretase
Over-expression of the c-myc proto-oncogene in colorectal carcinoma.
Smith DR, et al.
British Journal of Cancer, 68(2) (1993)
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Caifeng Yan, et al.
Scientific Reports (2016)
Zixing Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(19), E4522-E4531 (2018-04-25)
Abscisic acid (ABA) plays essential roles in plant development and responses to environmental stress. ABA induces subcellular translocation and degradation of the guanine nucleotide exchange factor RopGEF1, thus facilitating ABA core signal transduction. However, the underlying mechanisms for ABA-triggered RopGEF1
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Nasim A, et al.
Proceedings of the National Academy of Sciences of the USA, 107(21), 9742-9746 (2010)

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