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SAB2101106

Sigma-Aldrich

Anti-HTR2A antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-5-HT2A, Anti-5-hydroxytryptamine (serotonin) receptor 2A, Anti-HTR2
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

52 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HTR2A(3356)

General description

5-hydroxytryptamine receptor 2A (HTR2A) encodes for a G-Protein coupled serotonin receptor. HTR2A is predominantly expressed in the brain near to serotoninergic neurons. The gene HTR2A is localized on human chromosome on 13q14.2.

Immunogen

Synthetic peptide directed towards the N terminal region of human HTR2A

Biochem/physiol Actions

5-hydroxytryptamine receptor 2A (HTR2A) binds to neurotransmitters or drugs and activates the G-protein coupled signalling pathway by stimulating phospholipase C signalling cascade and the ultimate release of calcium. and modulates cognitive functions, memory, learning etc. HTR2A is the drug targeting receptor for many of the antipsychotic drugs like serotonergic psychedelics. Genetic polymorphisms as well as epigenetic factors regulate the expression of HTR2A. These variations in the regulation lead to a wide variety of psychotic disorders like schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer′s disease.

Sequence

Synthetic peptide located within the following region: DILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSEN

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder
Abdolmaleky HM, et al.
Schizophrenia Research, 129(2-3), 183-190 (2011)
Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression
Myers RL, et al.
Biological Psychiatry, 61(2), 167-173 (2007)
Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment
Horstmann S, et al.
Neuropsychopharmacology, 35(3), 727-740 (2010)
Functional selectivity and classical concepts of quantitative pharmacology
Urban JD, et al.
Journal of Pharmacology and Experimental Therapeutics, 320(1), 1-13 (2007)
The role of serotonin 5-HT2A receptors in memory and cognition
Zhang G and Stackman Jr RW
Frontiers in Pharmacology, 6, 225-225 (2015)

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