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SAB2500458

Sigma-Aldrich

Anti-GCNT3 (AA 410-422) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-C2/4GnT, Anti-C2GnT-M, Anti-C2GnT2, Anti-N-Acetylglucosaminyltransferase 3
NACRES:
NA.41

biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse, canine

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GCNT3(9245)

General description

The GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type) gene codes for an enzyme synthesizing the core of mucin protein and is mapped to human chromosome 15q22.2. The enzyme is predominantly expressed in stomach and colon.

Immunogen

Peptide with sequence C-NKFDPKVDDNALQ from the internal region (near C terminus) of the protein sequence according to NP_004742.1.

Biochem/physiol Actions

Gcnt3 (glucosaminyl (N-acetyl) transferase 3, mucin type) is involved in the biosynthesis of core 2, core 4 and blood group I antigen in secreted mucins. Overexpression of GCNT3 gene is observed in human pancreatic cancer and contributes to elevated mucin formation, aggressive tumorigenesis and decreased patient survival. The GCNT3 gene is known to promote cell proliferation and spheroid formation in tumors. Deletion of GCNT3 gene results in loss of core 2 O-glycan in the stomach and colon.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Core 2 Mucin-Type O-Glycan Is Related to EPEC and EHEC O157:H7 Adherence to Human Colon Carcinoma HT-29 Epithelial Cells.
Jun Y, et al.
Digestive Diseases and Sciences, 60(7), 1977?1990-1977?1990 (2015)
Allelic Skewing of DNA Methylation Is Widespread across the Genome.
Leonard C S, et al.
American Journal of Human Genetics, 86(2), 196-212 (2010)
Molecular Pathways: Mucins and Drug Delivery in Cancer.
Chinthalapally V R, et al.
Clinical Cancer Research (2017)
Keratin 1 Plays a Critical Role in Golgi Localization of Core 2 N-Acetylglucosaminyltransferase M via Interaction with Its Cytoplasmic Tail.
Armen P, et al.
The Journal of Biological Chemistry, 290(10), 6256-6269 (2015)

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